Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0003 | 0.00000011306 | 0.00000044659 |
Brugia malayi | olfactory channel protein osm-9 | 0.0003 | 0.0017 | 0.0065 |
Schistosoma mansoni | transient receptor potential channel | 0.0003 | 0.00000011306 | 0.00000011306 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0003 | 0.0017 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0003 | 0.00000011306 | 0.00000044659 |
Schistosoma mansoni | transient receptor potential channel | 0.0003 | 0.0017 | 0.0017 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0003 | 0.00000011306 | 0.00000011306 |
Onchocerca volvulus | 0.004 | 0.2532 | 1 | |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0003 | 0.0017 | 0.0017 |
Brugia malayi | NADH dehydrogenase subunit 1 | 0.004 | 0.2532 | 1 |
Loa Loa (eye worm) | NADH dehydrogenase subunit 1 | 0.004 | 0.2532 | 1 |
Brugia malayi | NADH dehydrogenase subunit 1, identical | 0.004 | 0.2532 | 1 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0003 | 0.0017 | 1 |
Schistosoma mansoni | NADH dehydrogenase subunit 1 | 0.004 | 0.2532 | 0.2532 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0003 | 0.00000011306 | 0.00000011306 |
Loa Loa (eye worm) | hypothetical protein | 0.0003 | 0.0017 | 0.0065 |
Onchocerca volvulus | 0.004 | 0.2532 | 1 | |
Schistosoma mansoni | transient receptor potential channel | 0.0003 | 0.00000011306 | 0.00000011306 |
Brugia malayi | hypothetical protein | 0.004 | 0.2532 | 1 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0003 | 0.00000011306 | 0.0001 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0003 | 0.0017 | 0.9999 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0003 | 0.0017 | 0.0017 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI (functional) | = 49 % | Antitrypanosomal activity against Trypanosoma cruzi Tulahuen 2 epimastigotes assessed as growth inhibition at 25 uM after 5 days relative to control | ChEMBL. | 21506600 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.