Detailed information for compound 1512556

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 326.408 | Formula: C20H23FN2O
  • H donors: 2 H acceptors: 1 LogP: 4.71 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(CC(c1c[nH]c2c1cc(F)cc2)N(Cc1ccccc1)O)C
  • InChi: 1S/C20H23FN2O/c1-14(2)10-20(23(24)13-15-6-4-3-5-7-15)18-12-22-19-9-8-16(21)11-17(18)19/h3-9,11-12,14,20,22,24H,10,13H2,1-2H3
  • InChiKey: PAQQKGSBFKPSFD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0033 0.0047 0.0087
Brugia malayi Muscleblind-like protein 0.0144 0.1508 0.2807
Schistosoma mansoni glycogen phosphorylase 0.0189 0.2101 0.3912
Echinococcus granulosus nAChR subunit 0.0035 0.0065 0.0122
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0064 0.0455 0.0847
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0064 0.0455 0.0847
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0064 0.0455 0.0847
Loa Loa (eye worm) hypothetical protein 0.0064 0.0455 0.0847
Schistosoma mansoni nAChR subunit 0.0064 0.0455 0.0847
Brugia malayi Cation transporter family protein 0.021 0.2374 0.4419
Loa Loa (eye worm) hypothetical protein 0.0035 0.0065 0.0122
Loa Loa (eye worm) GABA receptor subunit 0.0035 0.0065 0.0122
Loa Loa (eye worm) hypothetical protein 0.0064 0.0455 0.0847
Loa Loa (eye worm) hypothetical protein 0.0035 0.0065 0.0122
Echinococcus granulosus glycine receptor subunit alpha 1 0.0064 0.0455 0.0847
Loa Loa (eye worm) hypothetical protein 0.0064 0.0455 0.0847
Brugia malayi hypothetical protein 0.007 0.0528 0.0983
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0064 0.0455 0.0455
Onchocerca volvulus 0.0035 0.0065 0.0122
Schistosoma mansoni hypothetical protein 0.0033 0.0047 0.0087
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0064 0.0455 0.0847
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.021 0.2374 0.4419
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0064 0.0455 0.0847
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0064 0.0455 0.0847
Loa Loa (eye worm) hypothetical protein 0.0144 0.1508 0.2807
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0064 0.0455 0.0847
Loa Loa (eye worm) hypothetical protein 0.0035 0.0065 0.0122
Schistosoma mansoni hypothetical protein 0.007 0.0528 0.0983
Entamoeba histolytica glycogen phosphorylase, putative 0.0189 0.2101 0.3837
Giardia lamblia Glycogen phosphorylase 0.0438 0.5372 0.5
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0249 0.0464
Trichomonas vaginalis glycogen phosphorylase, putative 0.0438 0.5372 0.5
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0064 0.0455 0.0847
Entamoeba histolytica glycogen phosphorylase, putative 0.0438 0.5372 1
Loa Loa (eye worm) hypothetical protein 0.021 0.2374 0.4419
Chlamydia trachomatis glycogen phosphorylase 0.0438 0.5372 0.5
Loa Loa (eye worm) hypothetical protein 0.0064 0.0455 0.0847
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0035 0.0065 0.0122
Onchocerca volvulus 0.0064 0.0455 0.0847
Echinococcus granulosus glycine receptor subunit beta 0.0064 0.0455 0.0847
Entamoeba histolytica glycogen phosphorylase, putative 0.0438 0.5372 1
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0064 0.0455 0.0847
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0064 0.0455 0.0847
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0064 0.0455 0.0847
Echinococcus multilocularis muscleblind protein 0.0144 0.1508 0.1508
Loa Loa (eye worm) ACC-1 protein 0.0064 0.0455 0.0847
Echinococcus multilocularis nAChR subunit 0.0064 0.0455 0.0455
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0064 0.0455 0.0847
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0064 0.0455 0.0455
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0189 0.2101 0.5
Loa Loa (eye worm) hypothetical protein 0.0064 0.0455 0.0847
Echinococcus granulosus glycogen phosphorylase 0.0438 0.5372 1
Schistosoma mansoni hypothetical protein 0.0164 0.1763 0.3282
Loa Loa (eye worm) hypothetical protein 0.0064 0.0455 0.0847
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0035 0.0065 0.0122
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0064 0.0455 0.0455
Echinococcus multilocularis nAChR subunit 0.0035 0.0065 0.0065
Onchocerca volvulus 0.021 0.2374 0.4419
Loa Loa (eye worm) hypothetical protein 0.0064 0.0455 0.0847
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0064 0.0455 0.0847
Loa Loa (eye worm) hypothetical protein 0.0064 0.0455 0.0847
Echinococcus multilocularis muscleblind protein 1 0.0144 0.1508 0.1508
Loa Loa (eye worm) hypothetical protein 0.0064 0.0455 0.0847
Loa Loa (eye worm) hypothetical protein 0.0144 0.1508 0.2807
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0064 0.0455 0.0847
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.007 0.0528 0.0983
Echinococcus multilocularis glycine receptor subunit beta 0.0064 0.0455 0.0455
Schistosoma mansoni nAChR subunit 0.0064 0.0455 0.0847
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0035 0.0065 0.0122
Onchocerca volvulus Putative nachr subunit 0.0064 0.0455 0.0847
Schistosoma mansoni nAChR subunit 0.0064 0.0455 0.0847
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0064 0.0455 0.0847
Loa Loa (eye worm) hypothetical protein 0.0064 0.0455 0.0847
Schistosoma mansoni nAChR subunit 0.0064 0.0455 0.0847
Echinococcus granulosus glycine receptor subunit alpha 1 0.0064 0.0455 0.0847
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0064 0.0455 0.0455
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0064 0.0455 0.0847
Loa Loa (eye worm) hypothetical protein 0.0181 0.1984 0.3694
Entamoeba histolytica glycogenphosphorylase, putative 0.0189 0.2101 0.3837
Loa Loa (eye worm) hypothetical protein 0.0064 0.0455 0.0847
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0064 0.0455 0.0455
Entamoeba histolytica glycogen phosphorylase, putative 0.0189 0.2101 0.3837
Onchocerca volvulus 0.0064 0.0455 0.0847
Schistosoma mansoni nAChR subunit 0.0064 0.0455 0.0847
Brugia malayi carbohydrate phosphorylase 0.0438 0.5372 1
Loa Loa (eye worm) ACC-1 protein 0.0064 0.0455 0.0847
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0064 0.0455 0.0847
Onchocerca volvulus 0.0035 0.0065 0.0122
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0189 0.2101 0.5
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0047 0.0087
Entamoeba histolytica hypothetical protein 0.007 0.0528 0.0872
Entamoeba histolytica hypothetical protein 0.007 0.0528 0.0872
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0064 0.0455 0.0455
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0064 0.0455 0.0455
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0064 0.0455 0.0847
Entamoeba histolytica hypothetical protein 0.007 0.0528 0.0872
Onchocerca volvulus Glycogen phosphorylase homolog 0.0438 0.5372 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.0455 0.0847
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0064 0.0455 0.0847
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0064 0.0455 0.0455
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0064 0.0455 0.0847
Loa Loa (eye worm) hypothetical protein 0.0049 0.0249 0.0464
Schistosoma mansoni nAChR subunit 0.0064 0.0455 0.0847
Echinococcus granulosus Glycosyl transferase family 35 0.0438 0.5372 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.0455 0.0847
Loa Loa (eye worm) hypothetical protein 0.0035 0.0065 0.0122
Loa Loa (eye worm) hypothetical protein 0.0035 0.0065 0.0122
Loa Loa (eye worm) LGC-31 protein 0.0064 0.0455 0.0847
Schistosoma mansoni glycogen phosphorylase 0.0438 0.5372 1
Schistosoma mansoni nAChR subunit 0.0064 0.0455 0.0847
Trichomonas vaginalis glycogen phosphorylase, putative 0.0438 0.5372 0.5
Echinococcus multilocularis glycogen phosphorylase 0.0438 0.5372 0.5372
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0035 0.0065 0.0122
Loa Loa (eye worm) hypothetical protein 0.0064 0.0455 0.0847
Echinococcus granulosus glycine receptor subunit beta 0.0064 0.0455 0.0847
Echinococcus multilocularis geminin 0.0164 0.1763 0.1763
Loa Loa (eye worm) hypothetical protein 0.021 0.2374 0.4419
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0249 0.0464
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0064 0.0455 0.0847
Brugia malayi Cation transporter family protein 0.0064 0.0455 0.0847
Brugia malayi excitatory GABA receptor EXP-1A 0.0064 0.0455 0.0847
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0064 0.0455 0.0847
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0064 0.0455 0.0847
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0064 0.0455 0.0847
Schistosoma mansoni transcription factor LCR-F1 0.007 0.0528 0.0983
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0064 0.0455 0.0847
Loa Loa (eye worm) hypothetical protein 0.0064 0.0455 0.0847
Schistosoma mansoni neurotransmitter gated ion channel 0.0035 0.0065 0.0122
Echinococcus multilocularis glycogen phosphorylase 0.0438 0.5372 0.5372
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0249 0.0464
Echinococcus granulosus geminin 0.0164 0.1763 0.3282
Schistosoma mansoni hypothetical protein 0.0164 0.1763 0.3282
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0035 0.0065 0.0122
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0064 0.0455 0.0847
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0064 0.0455 0.0847
Loa Loa (eye worm) glycogen phosphorylase 0.0438 0.5372 1
Onchocerca volvulus 0.021 0.2374 0.4419
Loa Loa (eye worm) hypothetical protein 0.0035 0.0065 0.0122
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.007 0.0528 0.0528
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0064 0.0455 0.0847
Loa Loa (eye worm) hypothetical protein 0.0035 0.0065 0.0122
Echinococcus granulosus muscleblind protein 0.0144 0.1508 0.2807
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0064 0.0455 0.0847
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.021 0.2374 0.4419
Echinococcus granulosus nAChR subunit 0.0064 0.0455 0.0847
Echinococcus granulosus glycogen phosphorylase 0.0438 0.5372 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0064 0.0455 0.0455
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0064 0.0455 0.0847
Onchocerca volvulus 0.0064 0.0455 0.0847
Brugia malayi Cation transporter family protein 0.0064 0.0455 0.0847
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0064 0.0455 0.0455
Schistosoma mansoni glycogen phosphorylase 0.0438 0.5372 1
Echinococcus granulosus glycine receptor subunit alpha 1 0.0064 0.0455 0.0847
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0064 0.0455 0.0847
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0064 0.0455 0.0847
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0064 0.0455 0.0847
Echinococcus multilocularis glycine receptor subunit beta 0.0064 0.0455 0.0455
Onchocerca volvulus 0.021 0.2374 0.4419
Loa Loa (eye worm) hypothetical protein 0.0064 0.0455 0.0847
Loa Loa (eye worm) hypothetical protein 0.0064 0.0455 0.0847
Echinococcus multilocularis Glycosyl transferase, family 35 0.0438 0.5372 0.5372
Loa Loa (eye worm) hypothetical protein 0.0035 0.0065 0.0122
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0064 0.0455 0.0847
Entamoeba histolytica hypothetical protein 0.007 0.0528 0.0872
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0035 0.0065 0.0122

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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