Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | Probable anthranilate phosphoribosyltransferase TrpD | 0.0183 | 0.2542 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0596 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0057 | 0.052 | 1 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0062 | 0.0596 | 0.0324 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0042 | 0.0281 | 0.5392 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.005 | 0.0411 | 1 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0062 | 0.0596 | 0.0324 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0045 | 0.0335 | 0.8166 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 39 % | Competitive inhibition of recombinant TAK1-TAB1 assessed as [33P]gamma-ATP incorporation into substrate histone H1 peptide at 10 uM by filter plate assay | ChEMBL. | 21316225 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.