Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0064 | 0.6142 | 0.6142 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0064 | 0.6142 | 0.6142 |
Brugia malayi | hypothetical protein | 0.0066 | 0.6431 | 0.6431 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0064 | 0.6142 | 0.6435 |
Onchocerca volvulus | 0.0066 | 0.6431 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.6887 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.6142 | 0.6435 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.9544 | 1 |
Schistosoma mansoni | jun-related protein | 0.0068 | 0.6887 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 20 uM | Inhibition of AKT1 by IMAP assay | ChEMBL. | 21392984 |
IC50 (binding) | > 25 uM | Inhibition of AKT1 in human LNCaP cells assessed as PRAS40 phosphorylation at Thr246 after 1.5 hrs | ChEMBL. | 21392984 |
Inhibition (binding) | Inhibition of AKT2 by IMAP assay | ChEMBL. | 21392984 | |
Inhibition (binding) | Inhibition of AKT3 by IMAP assay | ChEMBL. | 21392984 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.