Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.004 | 0.1435 | 0.7399 |
Trypanosoma brucei | trypanothione reductase | 0.0093 | 1 | 1 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0072 | 0.664 | 0.664 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0053 | 0.3462 | 0.5 |
Loa Loa (eye worm) | glutathione reductase | 0.0093 | 1 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0093 | 1 | 1 |
Echinococcus granulosus | chromobox protein 1 | 0.0072 | 0.664 | 0.4862 |
Leishmania major | trypanothione reductase | 0.0093 | 1 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0053 | 0.3462 | 0.5 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0053 | 0.3462 | 0.5 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0093 | 1 | 1 |
Brugia malayi | Heterochromatin protein 1 | 0.0072 | 0.664 | 0.6199 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0053 | 0.3462 | 0.3894 |
Trichomonas vaginalis | chromobox protein, putative | 0.0043 | 0.1939 | 0.0969 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0093 | 1 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0053 | 0.3462 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1435 | 0.1435 |
Brugia malayi | Thioredoxin reductase | 0.0093 | 1 | 1 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0043 | 0.1939 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0072 | 0.664 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0093 | 1 | 1 |
Echinococcus granulosus | chromobox protein 1 | 0.0072 | 0.664 | 0.4862 |
Echinococcus multilocularis | chromobox protein 1 | 0.0072 | 0.664 | 0.4862 |
Echinococcus multilocularis | chromobox protein 1 | 0.0072 | 0.664 | 0.4862 |
Treponema pallidum | NADH oxidase | 0.0053 | 0.3462 | 0.5 |
Schistosoma mansoni | chromobox protein | 0.0072 | 0.664 | 0.4862 |
Trichomonas vaginalis | chromobox protein, putative | 0.0072 | 0.664 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0093 | 1 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0093 | 1 | 1 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0053 | 0.3462 | 0.3894 |
Plasmodium vivax | glutathione reductase, putative | 0.0093 | 1 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0093 | 1 | 1 |
Schistosoma mansoni | chromobox protein | 0.0072 | 0.664 | 0.4862 |
Trichomonas vaginalis | chromobox protein, putative | 0.0043 | 0.1939 | 0.0969 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0053 | 0.3462 | 0.5 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0053 | 0.3462 | 0.2603 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0053 | 0.3462 | 0.5 |
Plasmodium falciparum | glutathione reductase | 0.0093 | 1 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0053 | 0.3462 | 0.5 |
Brugia malayi | chromobox protein homolog 3 | 0.004 | 0.1435 | 0.0309 |
Toxoplasma gondii | thioredoxin reductase | 0.0093 | 1 | 1 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0053 | 0.3462 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 34 nM | Binding affinity towards 5-hydroxytryptamine 3 receptor by displacement of [3H]-2 in Neuroblastoma-Glioma NG-108-15 cells | ChEMBL. | 2213824 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.