Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | calcitonin receptor-like | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | calcitonin receptor-like | 461 aa | 434 aa | 28.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0077 | 0.9156 | 1 | |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0077 | 0.9156 | 0.9156 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0077 | 0.9156 | 0.9156 |
Onchocerca volvulus | 0.0077 | 0.9156 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.234 | 0.234 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.5596 | 0.5596 |
Onchocerca volvulus | 0.0077 | 0.9156 | 1 | |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0077 | 0.9156 | 0.9156 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.5596 | 0.5596 |
Onchocerca volvulus | 0.0044 | 0.234 | 0.2556 | |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0077 | 0.9156 | 0.9156 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.234 | 0.234 |
Onchocerca volvulus | 0.0077 | 0.9156 | 1 | |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0044 | 0.234 | 0.234 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.234 | 0.234 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0044 | 0.234 | 0.234 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.9156 | 0.9156 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0044 | 0.234 | 0.234 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0044 | 0.234 | 0.234 |
Onchocerca volvulus | 0.0077 | 0.9156 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.234 | 0.234 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.234 | 0.234 |
Onchocerca volvulus | 0.0044 | 0.234 | 0.2556 | |
Onchocerca volvulus | 0.0077 | 0.9156 | 1 | |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0044 | 0.234 | 0.234 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.5596 | 0.5596 |
Brugia malayi | hypothetical protein | 0.0044 | 0.234 | 0.234 |
Brugia malayi | hypothetical protein | 0.0044 | 0.234 | 0.234 |
Onchocerca volvulus | 0.0077 | 0.9156 | 1 | |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.5596 | 0.5596 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1669 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.1669 | 0.1669 |
Onchocerca volvulus | 0.0077 | 0.9156 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1669 | 0.1669 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.61 nM | Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay | ChEMBL. | 21251825 |
IC50 (functional) | = 1.7 nM | Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assay in presence of 50% human serum | ChEMBL. | 21251825 |
Ki (binding) | = 0.14 nM | Displacement of [125I]-CGRP from human recombinant CGRP receptor | ChEMBL. | 21251825 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.