Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.4536 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.4536 | 0.4536 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.4536 | 0.4536 |
Brugia malayi | hypothetical protein | 0.0035 | 0.4536 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.4536 | 0.4536 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.4536 | 0.4536 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.4536 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.4536 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.4536 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 62.79 uM | Inhibition of SARS coronavirus recombinant 3C-like protease expressed in Escherichia coli BL21(DE3) after 30 mins by FRET based assay | ChEMBL. | 21470860 |
Inhibition (binding) | = 61.36 % | Inhibition of SARS coronavirus recombinant 3C-like protease expressed in Escherichia coli BL21(DE3) at 100 uM after 18 mins by FRET based assay | ChEMBL. | 21470860 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.