Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | transglutaminase 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Probable DNA topoisomerase II | 0.0643 | 0.1747 | 1 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0446 | 0.0977 | 0.1791 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0643 | 0.1747 | 0.3202 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0446 | 0.0977 | 0.1791 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.1591 | 0.5455 | 1 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0643 | 0.1747 | 1 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.1805 | 0.6292 | 0.6292 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0643 | 0.1747 | 1 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0446 | 0.0977 | 0.1791 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0643 | 0.1747 | 1 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0643 | 0.1747 | 0.1747 |
Giardia lamblia | DNA topoisomerase II | 0.0557 | 0.1409 | 1 |
Mycobacterium leprae | Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0948 | 0.2938 | 1 |
Leishmania major | DNA topoisomerase ii | 0.0446 | 0.0977 | 0.1791 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.1591 | 0.5455 | 1 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0643 | 0.1747 | 0.1747 |
Loa Loa (eye worm) | hypothetical protein | 0.0446 | 0.0977 | 0.5592 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0643 | 0.1747 | 1 |
Schistosoma mansoni | DNA topoisomerase II | 0.0643 | 0.1747 | 1 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0643 | 0.1747 | 1 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0643 | 0.1747 | 1 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0643 | 0.1747 | 1 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0643 | 0.1747 | 1 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0446 | 0.0977 | 0.1791 |
Loa Loa (eye worm) | hypothetical protein | 0.0446 | 0.0977 | 0.5592 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.1591 | 0.5455 | 1 |
Trypanosoma brucei | DNA topoisomerase ii | 0.1591 | 0.5455 | 1 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0643 | 0.1747 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.1591 | 0.5455 | 1 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0643 | 0.1747 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 18 uM | Inhibition of human transglutaminase 2 using Cbz-Gln-Gly as a substrate by GDH-coupled assay | ChEMBL. | 21215619 |
Ki (binding) | = 10 uM | Inhibition of human transglutaminase 2 using Cbz-Gln-Gly as a substrate by GDH-coupled assay | ChEMBL. | 21215619 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.