Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | peptide deformylase (mitochondrial) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Leishmania major | polypeptide deformylase-like protein, putative | peptide deformylase (mitochondrial) | 243 aa | 207 aa | 27.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0266 | 0.9405 | 0.9719 |
Loa Loa (eye worm) | hypothetical protein | 0.0271 | 0.9658 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0264 | 0.9322 | 0.9322 |
Echinococcus multilocularis | geminin | 0.0194 | 0.6163 | 0.6381 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.009 | 0.1405 | 0.1405 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.0279 | 1 | 1 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.0279 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.0279 | 1 | 1 |
Treponema pallidum | polypeptide deformylase (def) | 0.0279 | 1 | 1 |
Brugia malayi | Probable ClpP-like protease | 0.009 | 0.1405 | 0.0858 |
Plasmodium falciparum | peptide deformylase | 0.0279 | 1 | 1 |
Plasmodium vivax | peptide deformylase, putative | 0.0279 | 1 | 1 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0106 | 0.2163 | 0.5 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.0106 | 0.2163 | 0.5 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0106 | 0.2163 | 0.5 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.009 | 0.1405 | 0.1455 |
Toxoplasma gondii | hypothetical protein | 0.0279 | 1 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0271 | 0.9658 | 1 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0106 | 0.2163 | 0.5 |
Echinococcus granulosus | geminin | 0.0194 | 0.6163 | 0.6381 |
Brugia malayi | hypothetical protein | 0.0271 | 0.9658 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.1405 | 0.0858 |
Schistosoma mansoni | hypothetical protein | 0.0194 | 0.6163 | 1 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.0106 | 0.2163 | 0.5 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.009 | 0.1405 | 0.1455 |
Echinococcus granulosus | tar DNA binding protein | 0.0073 | 0.063 | 0.0653 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0271 | 0.9658 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0073 | 0.063 | 0.0653 |
Schistosoma mansoni | hypothetical protein | 0.0194 | 0.6163 | 1 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.009 | 0.1405 | 0.14 |
Trypanosoma brucei | Peptide deformylase 2 | 0.0106 | 0.2163 | 0.5 |
Mycobacterium ulcerans | peptide deformylase | 0.0279 | 1 | 1 |
Brugia malayi | follicle stimulating hormone receptor | 0.0266 | 0.9405 | 0.9719 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0106 | 0.2163 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 30 nM | Inhibition against Escherichia coli peptide deformylase | ChEMBL. | 12873499 |
IC50 (binding) | = 30 nM | Inhibition against Escherichia coli peptide deformylase | ChEMBL. | 12873499 |
MIC (functional) | = 50 uM | Antibacterial activity against Escherichia coli | ChEMBL. | 12873499 |
MIC (functional) | = 50 uM | Antibacterial activity against Escherichia coli | ChEMBL. | 12873499 |
MIC (functional) | > 200 uM | Antibacterial activity against Staphylococcus capitis | ChEMBL. | 12873499 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.