Detailed information for compound 151471

Basic information

Technical information
  • TDR Targets ID: 151471
  • Name: N-(4-ethylphenyl)-4-pyridin-4-ylpyrimidin-2-a mine
  • MW: 276.336 | Formula: C17H16N4
  • H donors: 1 H acceptors: 3 LogP: 3.47 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1ccc(cc1)Nc1nccc(n1)c1ccncc1
  • InChi: 1S/C17H16N4/c1-2-13-3-5-15(6-4-13)20-17-19-12-9-16(21-17)14-7-10-18-11-8-14/h3-12H,2H2,1H3,(H,19,20,21)
  • InChiKey: ZQURSDASJNGYGJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(4-ethylphenyl)-4-(4-pyridyl)pyrimidin-2-amine
  • N-(4-ethylphenyl)-4-(4-pyridyl)-2-pyrimidinamine
  • N-(4-ethylphenyl)-4-pyridin-4-yl-pyrimidin-2-amine
  • (4-ethylphenyl)-[4-(4-pyridyl)pyrimidin-2-yl]amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0417 0.0417
Echinococcus multilocularis glycine receptor subunit alpha 1 0.002 0.0342 0.0342
Loa Loa (eye worm) hypothetical protein 0.002 0.0342 0.0342
Loa Loa (eye worm) hypothetical protein 0.002 0.0342 0.0342
Loa Loa (eye worm) hypothetical protein 0.0011 0.0049 0.0049
Loa Loa (eye worm) LGC-31 protein 0.002 0.0342 0.0342
Loa Loa (eye worm) hypothetical protein 0.002 0.0342 0.0342
Loa Loa (eye worm) GABA receptor subunit 0.0011 0.0049 0.0049
Onchocerca volvulus Glycogen phosphorylase homolog 0.0123 0.36 1
Brugia malayi Cation transporter family protein 0.002 0.0342 0.0951
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0342 0.0951
Loa Loa (eye worm) hypothetical protein 0.002 0.0342 0.0342
Echinococcus multilocularis glycine receptor subunit alpha 1 0.002 0.0342 0.0342
Loa Loa (eye worm) hypothetical protein 0.002 0.0342 0.0342
Loa Loa (eye worm) hypothetical protein 0.0011 0.0049 0.0049
Plasmodium vivax importin-beta 2, putative 0.003 0.0671 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0011 0.0049 0.0137
Schistosoma mansoni importin beta-1 0.003 0.0671 0.0671
Schistosoma mansoni glycogen phosphorylase 0.0123 0.36 0.36
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.002 0.0342 0.0951
Onchocerca volvulus 0.002 0.0342 0.0951
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.002 0.0342 0.0342
Echinococcus multilocularis snurportin 1 0.0324 1 1
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.002 0.0342 0.0342
Schistosoma mansoni hypothetical protein 0.0324 1 1
Entamoeba histolytica glycogen phosphorylase, putative 0.0053 0.139 0.3776
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0324 1 1
Echinococcus granulosus glycine receptor subunit alpha 1 0.002 0.0342 0.0342
Giardia lamblia Glycogen phosphorylase 0.0123 0.36 1
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.002 0.0342 0.0342
Brugia malayi excitatory GABA receptor EXP-1A 0.002 0.0342 0.0951
Onchocerca volvulus 0.002 0.0342 0.0951
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0053 0.139 0.5
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0417 0.0417
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.002 0.0342 0.0342
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0489 1
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.002 0.0342 0.0342
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0011 0.0049 0.0137
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0011 0.0049 0.0137
Chlamydia trachomatis glycogen phosphorylase 0.0123 0.36 0.5
Schistosoma mansoni nAChR subunit 0.002 0.0342 0.0342
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.002 0.0342 0.0342
Brugia malayi carbohydrate phosphorylase 0.0123 0.36 1
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.002 0.0342 0.0951
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0011 0.0049 0.0137
Echinococcus multilocularis nAChR subunit 0.0011 0.0049 0.0049
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.002 0.0342 0.0342
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0671 1
Echinococcus granulosus glycogen phosphorylase 0.0123 0.36 0.36
Loa Loa (eye worm) hypothetical protein 0.002 0.0342 0.0342
Loa Loa (eye worm) hypothetical protein 0.002 0.0342 0.0342
Echinococcus multilocularis nAChR subunit 0.002 0.0342 0.0342
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.002 0.0342 0.0342
Plasmodium falciparum importin beta, putative 0.003 0.0671 1
Schistosoma mansoni nAChR subunit 0.002 0.0342 0.0342
Loa Loa (eye worm) hypothetical protein 0.002 0.0342 0.0342
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.002 0.0342 0.0951
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0489 0.0227
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.002 0.0342 0.0342
Echinococcus granulosus glycine receptor subunit beta 0.002 0.0342 0.0342
Echinococcus granulosus importin subunit beta 1 0.003 0.0671 0.0671
Onchocerca volvulus Putative nachr subunit 0.002 0.0342 0.0951
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.002 0.0342 0.0342
Entamoeba histolytica glycogenphosphorylase, putative 0.0053 0.139 0.3776
Onchocerca volvulus 0.002 0.0342 0.0951
Echinococcus multilocularis importin subunit beta 1 0.003 0.0671 0.0671
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.002 0.0342 0.0951
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0342 0.0951
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.002 0.0342 0.0951
Brugia malayi Cation transporter family protein 0.002 0.0342 0.0951
Onchocerca volvulus 0.002 0.0342 0.0951
Schistosoma mansoni nAChR subunit 0.002 0.0342 0.0342
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.002 0.0342 0.0342
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.002 0.0342 0.0951
Echinococcus multilocularis glycine receptor subunit beta 0.002 0.0342 0.0342
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0417 0.1157
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0342 0.0951
Loa Loa (eye worm) hypothetical protein 0.0011 0.0049 0.0049
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.002 0.0342 0.0342
Leishmania major importin beta-1 subunit, putative 0.0025 0.0489 1
Entamoeba histolytica hypothetical protein 0.0025 0.0489 0.1238
Loa Loa (eye worm) hypothetical protein 0.002 0.0342 0.0342
Schistosoma mansoni nAChR subunit 0.002 0.0342 0.0342
Loa Loa (eye worm) hypothetical protein 0.002 0.0342 0.0342
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.002 0.0342 0.0342
Schistosoma mansoni nAChR subunit 0.002 0.0342 0.0342
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.002 0.0342 0.0951
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0489 0.0227
Echinococcus granulosus glycine receptor subunit beta 0.002 0.0342 0.0342
Trichomonas vaginalis glycogen phosphorylase, putative 0.0123 0.36 1
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.002 0.0342 0.0342
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0417 0.0417
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.002 0.0342 0.0342
Schistosoma mansoni ran 0.0022 0.0417 0.0417
Loa Loa (eye worm) hypothetical protein 0.0011 0.0049 0.0049
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0671 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.002 0.0342 0.0342
Loa Loa (eye worm) hypothetical protein 0.002 0.0342 0.0342
Onchocerca volvulus 0.002 0.0342 0.0951
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.002 0.0342 0.0342
Entamoeba histolytica glycogen phosphorylase, putative 0.0123 0.36 1
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.002 0.0342 0.0951
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0053 0.139 0.5
Brugia malayi Importin beta-1 subunit 0.003 0.0671 0.1864
Loa Loa (eye worm) ACC-1 protein 0.002 0.0342 0.0342
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.002 0.0342 0.0342
Onchocerca volvulus 0.0011 0.0049 0.0137
Echinococcus granulosus nAChR subunit 0.002 0.0342 0.0342
Loa Loa (eye worm) hypothetical protein 0.002 0.0342 0.0342
Entamoeba histolytica glycogen phosphorylase, putative 0.0123 0.36 1
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.002 0.0342 0.0951
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.002 0.0342 0.0342
Echinococcus multilocularis glycogen phosphorylase 0.0123 0.36 0.36
Loa Loa (eye worm) glycogen phosphorylase 0.0123 0.36 0.36
Schistosoma mansoni neurotransmitter gated ion channel 0.0011 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.002 0.0342 0.0342
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0011 0.0049 0.0049
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0342 0.0951
Echinococcus multilocularis Glycosyl transferase, family 35 0.0123 0.36 0.36
Echinococcus granulosus glycine receptor subunit alpha 1 0.002 0.0342 0.0342
Schistosoma mansoni glycogen phosphorylase 0.0053 0.139 0.139
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0342 0.0951
Schistosoma mansoni glycogen phosphorylase 0.0123 0.36 0.36
Loa Loa (eye worm) hypothetical protein 0.002 0.0342 0.0342
Loa Loa (eye worm) hypothetical protein 0.0011 0.0049 0.0049
Brugia malayi Cation transporter family protein 0.002 0.0342 0.0951
Loa Loa (eye worm) ACC-1 protein 0.002 0.0342 0.0342
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0489 0.0227
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.002 0.0342 0.0342
Loa Loa (eye worm) hypothetical protein 0.002 0.0342 0.0342
Echinococcus granulosus nAChR subunit 0.0011 0.0049 0.0049
Entamoeba histolytica glycogen phosphorylase, putative 0.0053 0.139 0.3776
Trichomonas vaginalis glycogen phosphorylase, putative 0.0123 0.36 1
Onchocerca volvulus 0.0011 0.0049 0.0137
Loa Loa (eye worm) hypothetical protein 0.003 0.0671 0.0671
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0671 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0049 0.0049
Schistosoma mansoni nAChR subunit 0.002 0.0342 0.0342
Echinococcus granulosus Glycosyl transferase family 35 0.0123 0.36 0.36
Entamoeba histolytica Ran family GTPase 0.0022 0.0417 0.1034
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.002 0.0342 0.0342
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.002 0.0342 0.0342
Loa Loa (eye worm) hypothetical protein 0.002 0.0342 0.0342
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.002 0.0342 0.0342
Echinococcus multilocularis glycine receptor subunit alpha 1 0.002 0.0342 0.0342
Schistosoma mansoni nAChR subunit 0.002 0.0342 0.0342
Schistosoma mansoni ran 0.0022 0.0417 0.0417
Loa Loa (eye worm) hypothetical protein 0.0011 0.0049 0.0049
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.002 0.0342 0.0951
Loa Loa (eye worm) hypothetical protein 0.0011 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.002 0.0342 0.0342
Echinococcus multilocularis glycogen phosphorylase 0.0123 0.36 0.36
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0011 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.002 0.0342 0.0342
Brugia malayi RNA, U transporter 1 0.0086 0.2449 0.6802
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.002 0.0342 0.0342
Echinococcus multilocularis glycine receptor subunit beta 0.002 0.0342 0.0342
Echinococcus granulosus glycine receptor subunit alpha 1 0.002 0.0342 0.0342
Echinococcus granulosus glycogen phosphorylase 0.0123 0.36 0.36
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.002 0.0342 0.0342
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.002 0.0342 0.0342
Onchocerca volvulus 0.002 0.0342 0.0951
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.002 0.0342 0.0342
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.002 0.0342 0.0342
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0342 0.0951

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 7.7 uM In vitro inhibition of histamine release from human basophils ChEMBL. 8410986
IC50 (functional) = 7.7 uM In vitro inhibition of histamine release from human basophils ChEMBL. 8410986

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 8410986

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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