Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.007 | 0.4433 | 0.4433 |
Echinococcus granulosus | glutamate receptor 2 | 0.0061 | 0.3459 | 0.3459 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0066 | 0.3934 | 0.3934 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0061 | 0.3459 | 0.3459 |
Echinococcus granulosus | glutamate receptor 2 | 0.007 | 0.4433 | 0.4433 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0066 | 0.3934 | 0.3026 |
Echinococcus multilocularis | glutamate receptor 4 | 0.0041 | 0.1302 | 0.1302 |
Mycobacterium tuberculosis | Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) | 0.0042 | 0.1423 | 0.5 |
Echinococcus granulosus | glutamate receptor subunit protein glur | 0.005 | 0.2276 | 0.2276 |
Echinococcus granulosus | glutamate receptor 1 | 0.0041 | 0.1302 | 0.1302 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.004 | 0.1219 | 0.0142 |
Echinococcus granulosus | glutamate receptor 4 | 0.0041 | 0.1302 | 0.1302 |
Echinococcus multilocularis | glutamate receptor 2 | 0.007 | 0.4433 | 0.4433 |
Echinococcus multilocularis | glutamate receptor subunit protein glur | 0.005 | 0.2276 | 0.2276 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.007 | 0.4433 | 0.4433 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 70.7946 uM | PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.