Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nucleotide-binding oligomerization domain containing 2 | Starlite/ChEMBL | References |
Homo sapiens | nucleotide-binding oligomerization domain containing 1 | Starlite/ChEMBL | References |
Homo sapiens | tumor necrosis factor | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | caspase-7 (C14 family) | 0.0075 | 0.5 | 0.5 |
Brugia malayi | hypothetical protein | 0.0075 | 0.5 | 0.5 |
Echinococcus granulosus | apoptotic protease activating factor 1 | 0.0075 | 0.5 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0075 | 0.5 | 0.5 |
Echinococcus granulosus | caspase 2 | 0.0075 | 0.5 | 0.5 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0075 | 0.5 | 0.5 |
Echinococcus multilocularis | apoptotic protease activating factor 1 | 0.0075 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.5 | 0.5 |
Echinococcus multilocularis | caspase 2 | 0.0075 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0075 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | = 0 % | Cytotoxicity against HEK293T cells at 20 uM by alamar blue assay | ChEMBL. | 22003428 |
IC50 (functional) | = 5.87 uM | PUBCHEM_BIOASSAY: SAR analysis of compounds that inhibit NOD1 revised. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1575, AID1578, AID2335, AID2466, AID2469, AID2505, AID2798, AID2800] | ChEMBL. | No reference |
IC50 (binding) | = 5.87 uM | Inhibition of NOD-1 mediated NFkappaB activation in HEK293T cells assessed as inhibition of gamma-tri-DAP-induced luciferase activity after 14 hrs by reporter gene assay | ChEMBL. | 22003428 |
IC50 (functional) | = 8.79 uM | PUBCHEM_BIOASSAY: SAR analysis of inhibitors of TNFa specific NF-kB induction revised. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1566, AID1575, AID1578, AID1579, AID1852, AID2469, AID2483, AID2485, AID2800, AID2801] | ChEMBL. | No reference |
IC50 (functional) | = 9.24 uM | PUBCHEM_BIOASSAY: SAR analysis of compounds that inhibit NOD2 revised. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1566, AID1575, AID1578, AID1579, AID1848, AID1849, AID1852, AID2469, AID2475, AID2799, AID2800] | ChEMBL. | No reference |
IC50 (binding) | = 9.24 uM | Inhibition of NOD-2 mediated NFkappaB activation in HEK293T cells assessed as inhibition of MDP-induced luciferase activity after 14 hrs by reporter gene assay | ChEMBL. | 22003428 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.