Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0594 | 1 | 0.5 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0594 | 1 | 1 |
Echinococcus granulosus | prolyl endopeptidase | 0.0594 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0532 | 0.8259 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0594 | 1 | 0.5 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0594 | 1 | 1 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0236 | 0 | 0.5 |
Onchocerca volvulus | Prolyl endopeptidase homolog | 0.0594 | 1 | 0.5 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0236 | 0 | 0.5 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0594 | 1 | 0.5 |
Toxoplasma gondii | prolyl endopeptidase | 0.0594 | 1 | 0.5 |
Trypanosoma brucei | prolyl endopeptidase | 0.0594 | 1 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0594 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 100 uM | Concentration required for 50% inhibition of binding against Angiotensin II receptor in the rat adrenal cortex tissue | ChEMBL. | No reference |
IC50 (binding) | = 100 uM | Concentration required for 50% inhibition of binding against Angiotensin II receptor in the rat adrenal cortex tissue | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.