Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0019 | 0.006 | 0.0091 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0059 | 0.07 | 1 |
Schistosoma mansoni | lozenge | 0.0054 | 0.0619 | 0.0649 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0015 | 0 | 0.5 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0059 | 0.07 | 0.0643 |
Echinococcus granulosus | ankyrin repeat protein | 0.0163 | 0.2374 | 0.2327 |
Plasmodium vivax | kinesin-5 | 0.0083 | 0.1084 | 1 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0166 | 0.2427 | 0.2381 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0059 | 0.07 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.0053 | 0.0614 | 0.0643 |
Plasmodium falciparum | kinesin-5 | 0.0083 | 0.1084 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.07 | 0.0743 |
Giardia lamblia | Kinesin-5 | 0.0083 | 0.1084 | 0.5 |
Schistosoma mansoni | kinesin eg-5 | 0.0083 | 0.1084 | 0.1189 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0053 | 0.0614 | 0.0557 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0053 | 0.0614 | 0.0557 |
Loa Loa (eye worm) | hypothetical protein | 0.0429 | 0.6659 | 1 |
Brugia malayi | hypothetical protein | 0.0429 | 0.6659 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0553 | 0.8669 | 1 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0166 | 0.2427 | 0.2381 |
Entamoeba histolytica | kinesin, putative | 0.0083 | 0.1084 | 0.5 |
Echinococcus multilocularis | ankyrin repeat protein | 0.0163 | 0.2374 | 0.2327 |
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0083 | 0.1084 | 0.1628 |
Loa Loa (eye worm) | runx1 | 0.0054 | 0.0619 | 0.093 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.006 | 0.0091 |
Brugia malayi | Kinesin motor domain containing protein | 0.0083 | 0.1084 | 0.1628 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0025 | 0.0161 | 0.0242 |
Trypanosoma brucei | cytochrome P450, putative | 0.0015 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0429 | 0.6659 | 1 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.0083 | 0.1084 | 1 |
Brugia malayi | Doublecortin family protein | 0.0019 | 0.006 | 0.0091 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.07 | 1 |
Schistosoma mansoni | transient receptor potential cation channel subfamily A member | 0.0163 | 0.2374 | 0.2687 |
Loa Loa (eye worm) | doublecortin family protein | 0.0019 | 0.006 | 0.0091 |
Echinococcus multilocularis | kinesin family 1 | 0.0636 | 1 | 1 |
Echinococcus multilocularis | Protein lozenge | 0.0054 | 0.0619 | 0.0562 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.006 | 0.0091 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0015 | 0 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.07 | 0.0743 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.07 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.07 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0059 | 0.07 | 0.0643 |
Brugia malayi | Cytochrome P450 family protein | 0.0025 | 0.0161 | 0.0242 |
Onchocerca volvulus | 0.0429 | 0.6659 | 1 | |
Brugia malayi | hypothetical protein | 0.0019 | 0.006 | 0.0091 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = -6.62 % | Antiproliferative activity against mouse 3T3L1 cells after 48 hrs by MTT assay | ChEMBL. | 21515060 |
Inhibition (functional) | = 16.55 % | Inhibition of adipogenesis in mouse 3T3L1 cells at 100 umol/L after 8 days by Oil red O-staining | ChEMBL. | 21515060 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.