Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cytochrome P450, family 1, subfamily A, polypeptide 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Cytochrome P450 family protein | cytochrome P450, family 1, subfamily A, polypeptide 2 | 516 aa | 470 aa | 26.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | carbon monoxyde dehydrogenase medium chain CoxM | 0.0121 | 0.232 | 0.3502 |
Treponema pallidum | hypothetical protein | 0.0058 | 0.0291 | 1 |
Mycobacterium tuberculosis | Probable carbon monoxyde dehydrogenase (large chain) | 0.0169 | 0.3872 | 1 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase small chain CoxS | 0.0068 | 0.062 | 0.0568 |
Loa Loa (eye worm) | RNA binding protein | 0.0068 | 0.0613 | 1 |
Brugia malayi | TAR-binding protein | 0.0068 | 0.0613 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.0613 | 1 |
Brugia malayi | RNA binding protein | 0.0068 | 0.0613 | 1 |
Mycobacterium ulcerans | aerobic-type carbon monoxide dehydrogenase subunit CoxM_2 | 0.0121 | 0.232 | 0.3502 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0068 | 0.0613 | 1 |
Mycobacterium tuberculosis | Probable carbon monoxyde dehydrogenase (medium chain) | 0.0121 | 0.232 | 0.5229 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0068 | 0.0613 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.0613 | 1 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase small chain CoxS | 0.0068 | 0.062 | 0.0568 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase large chain CoxL | 0.0106 | 0.1843 | 0.2678 |
Echinococcus granulosus | tar DNA binding protein | 0.0068 | 0.0613 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.0613 | 1 |
Mycobacterium ulcerans | aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 | 0.0169 | 0.3872 | 0.618 |
Trichomonas vaginalis | xanthine dehydrogenase, putative | 0.0358 | 1 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0068 | 0.0613 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.0613 | 1 |
Mycobacterium ulcerans | carbon monoxide dehydrogenase | 0.0237 | 0.6086 | 1 |
Trichomonas vaginalis | aldehyde oxidase, putative | 0.0358 | 1 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0068 | 0.0613 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0068 | 0.0613 | 1 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase large chain CoxL | 0.0169 | 0.3872 | 0.618 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | = 0.398107171 uM | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.