Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | prokaryotic DNA topoisomerase | 0.0262 | 0.0616 | 0.2641 |
Loa Loa (eye worm) | DNA topoisomerase III beta-1 | 0.0262 | 0.0616 | 0.2731 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0855 | 0.2255 | 0.3701 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0855 | 0.2255 | 1 |
Trypanosoma brucei | DNA topoisomerase ii | 0.2116 | 0.5735 | 1 |
Schistosoma mansoni | prokaryotic DNA topoisomerase | 0.0262 | 0.0616 | 0.2641 |
Loa Loa (eye worm) | DNA topoisomerase III | 0.0262 | 0.0616 | 0.2731 |
Giardia lamblia | DNA topoisomerase III | 0.0262 | 0.0616 | 0.2347 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.366 | 1 | 1 |
Trypanosoma cruzi | DNA topoisomerase III, putative | 0.0262 | 0.0616 | 0.0734 |
Echinococcus multilocularis | Pyruvate dehydrogenase (lipoamide) kinase | 0.0115 | 0.021 | 0.0867 |
Entamoeba histolytica | DNA topoisomerase III, putative | 0.0262 | 0.0616 | 0.1983 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0855 | 0.2255 | 0.2089 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0855 | 0.2255 | 1 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0855 | 0.2255 | 1 |
Echinococcus granulosus | DNA topoisomerase 3 alpha | 0.0262 | 0.0616 | 0.2678 |
Plasmodium falciparum | DNA topoisomerase 3, putative | 0.0262 | 0.0616 | 0.0414 |
Trichomonas vaginalis | heat shock protein, putative | 0.0115 | 0.021 | 0.09 |
Plasmodium vivax | DNA topoisomerase 3, putative | 0.0262 | 0.0616 | 0.0414 |
Trichomonas vaginalis | receptor histidine kinase, putative | 0.0115 | 0.021 | 0.09 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.366 | 1 | 1 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.0262 | 0.0616 | 0.0734 |
Mycobacterium leprae | Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.126 | 0.3373 | 1 |
Trypanosoma cruzi | DNA topoisomerase III, putative | 0.0262 | 0.0616 | 0.0734 |
Trichomonas vaginalis | endoplasmin, putative | 0.0115 | 0.021 | 0.09 |
Treponema pallidum | DNA topoisomerase I (topA) | 0.0262 | 0.0616 | 0.0414 |
Trypanosoma cruzi | DNA topoisomerase IA, putative | 0.0262 | 0.0616 | 0.0734 |
Brugia malayi | GRF zinc finger family protein | 0.0262 | 0.0616 | 0.2678 |
Trypanosoma brucei | DNA topoisomerase III, putative | 0.0262 | 0.0616 | 0.0734 |
Brugia malayi | Endoplasmin precursor | 0.0115 | 0.021 | 0.0867 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0594 | 0.1533 | 0.2393 |
Brugia malayi | kinase, mitochondrial precursor | 0.0115 | 0.021 | 0.0867 |
Trichomonas vaginalis | two component sensor and regulator histidine kinase bacteria, putative | 0.0115 | 0.021 | 0.09 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0855 | 0.2255 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0855 | 0.2255 | 1 |
Schistosoma mansoni | endoplasmin | 0.0115 | 0.021 | 0.0821 |
Trichomonas vaginalis | sensor histidine kinase, putative | 0.0115 | 0.021 | 0.09 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.2116 | 0.5735 | 1 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0045 | 0.0016 | 0.0072 |
Echinococcus multilocularis | heat shock protein 90 | 0.0115 | 0.021 | 0.0867 |
Wolbachia endosymbiont of Brugia malayi | topoisomerase IA, TopA | 0.0262 | 0.0616 | 0.0414 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0594 | 0.1533 | 0.2393 |
Brugia malayi | heat shock protein 90 | 0.0115 | 0.021 | 0.0867 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0594 | 0.1533 | 0.2393 |
Loa Loa (eye worm) | endoplasmin | 0.0115 | 0.021 | 0.0933 |
Trichomonas vaginalis | prokaryotic DNA topoisomerase, putative | 0.0262 | 0.0616 | 0.2704 |
Echinococcus multilocularis | heat shock protein | 0.0115 | 0.021 | 0.0867 |
Trypanosoma cruzi | DNA topoisomerase III, putative | 0.0262 | 0.0616 | 0.0734 |
Trichomonas vaginalis | sensory transduction histidine kinase, putative | 0.0115 | 0.021 | 0.09 |
Schistosoma mansoni | pyruvate dehydrogenase | 0.0115 | 0.021 | 0.0821 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.366 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0594 | 0.1533 | 0.6796 |
Schistosoma mansoni | endoplasmin | 0.0115 | 0.021 | 0.0821 |
Chlamydia trachomatis | DNA topoisomerase I | 0.0262 | 0.0616 | 0.0414 |
Trichomonas vaginalis | heat shock protein, putative | 0.0115 | 0.021 | 0.09 |
Giardia lamblia | DNA topoisomerase III | 0.0262 | 0.0616 | 0.2347 |
Brugia malayi | DNA topoisomerase III beta-1 | 0.0262 | 0.0616 | 0.2678 |
Leishmania major | DNA topoisomerase ii | 0.0594 | 0.1533 | 0.2393 |
Schistosoma mansoni | heat shock protein | 0.0115 | 0.021 | 0.0821 |
Trypanosoma brucei | DNA topoisomerase IA, putative | 0.0262 | 0.0616 | 0.0734 |
Mycobacterium leprae | Probable DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) ( | 0.0262 | 0.0616 | 0.1282 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.021 | 0.0933 |
Trichomonas vaginalis | prokaryotic DNA topoisomerase, putative | 0.0262 | 0.0616 | 0.2704 |
Plasmodium falciparum | DNA gyrase subunit B | 0.366 | 1 | 1 |
Echinococcus granulosus | heat shock protein | 0.0115 | 0.021 | 0.0867 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0594 | 0.1533 | 0.2393 |
Schistosoma mansoni | DNA topoisomerase II | 0.0855 | 0.2255 | 1 |
Brugia malayi | DNA topoisomerase III | 0.0262 | 0.0616 | 0.2678 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.366 | 1 | 1 |
Toxoplasma gondii | DNA topoisomerase family protein | 0.0262 | 0.0616 | 0.0734 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.2116 | 0.5735 | 1 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.366 | 1 | 1 |
Trypanosoma brucei | DNA topoisomerase III, putative | 0.0262 | 0.0616 | 0.0734 |
Echinococcus multilocularis | rho GTPase activating protein 20 | 0.0262 | 0.0616 | 0.2678 |
Echinococcus granulosus | heat shock protein 90 | 0.0115 | 0.021 | 0.0867 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.2116 | 0.5735 | 1 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0855 | 0.2255 | 0.2089 |
Giardia lamblia | DNA topoisomerase II | 0.0741 | 0.1938 | 1 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0855 | 0.2255 | 1 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0855 | 0.2255 | 1 |
Trichomonas vaginalis | mismatch repair protein Mlh1C (mutL homolog) | 0.0115 | 0.021 | 0.09 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.24 | 0.652 | 0.6446 |
Echinococcus multilocularis | DNA topoisomerase 3 beta 1 | 0.0262 | 0.0616 | 0.2678 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0855 | 0.2255 | 1 |
Trichomonas vaginalis | sensory transduction histidine kinase bacterial, putative | 0.0115 | 0.021 | 0.09 |
Echinococcus granulosus | DNA topoisomerase 3 beta 1 | 0.0262 | 0.0616 | 0.2678 |
Trichomonas vaginalis | receptor histidine kinase, putative | 0.0115 | 0.021 | 0.09 |
Loa Loa (eye worm) | hypothetical protein | 0.0594 | 0.1533 | 0.6796 |
Loa Loa (eye worm) | heat shock protein 90 | 0.0115 | 0.021 | 0.0933 |
Leishmania major | DNA topoisomerase III, putative | 0.0262 | 0.0616 | 0.0734 |
Trypanosoma cruzi | DNA topoisomerase IA, putative | 0.0262 | 0.0616 | 0.0734 |
Mycobacterium ulcerans | DNA topoisomerase I | 0.0262 | 0.0616 | 0.0414 |
Entamoeba histolytica | DNA topoisomerase III, putative | 0.0262 | 0.0616 | 0.1983 |
Leishmania major | DNA topoisomerase III, putative | 0.0262 | 0.0616 | 0.0734 |
Echinococcus granulosus | Pyruvate dehydrogenase lipoamide kinase | 0.0115 | 0.021 | 0.0867 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0855 | 0.2255 | 1 |
Leishmania major | DNA topoisomerase 1A | 0.0262 | 0.0616 | 0.0734 |
Schistosoma mansoni | heat shock protein | 0.0115 | 0.021 | 0.0821 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0855 | 0.2255 | 1 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.2116 | 0.5735 | 1 |
Trichomonas vaginalis | sensory transduction histidine kinase bacterial, putative | 0.0115 | 0.021 | 0.09 |
Brugia malayi | Probable DNA topoisomerase II | 0.0855 | 0.2255 | 1 |
Echinococcus multilocularis | Pyruvate dehydrogenase (lipoamide) kinase | 0.0115 | 0.021 | 0.0867 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.