Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.0722 | 0.5 |
Brugia malayi | Hint module family protein | 0.0051 | 0 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.0118 | 0.4916 | 0.7559 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0061 | 0.0722 | 0.5 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0118 | 0.4916 | 0.4521 |
Echinococcus multilocularis | hedgehog | 0.0188 | 1 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0061 | 0.0722 | 0.5 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0061 | 0.0722 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0137 | 0.6271 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0083 | 0.2315 | 0.2871 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0118 | 0.4916 | 0.4521 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.0722 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.0722 | 0.5 |
Brugia malayi | Hint module family protein | 0.0051 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.