Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | transient receptor potential cation channel | 0.0007 | 1 | 1 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0007 | 1 | 1 |
Schistosoma mansoni | transient receptor potential channel | 0.0007 | 0.9999 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 1 | 1 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0007 | 1 | 1 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0007 | 0.9999 | 0.9999 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0007 | 0.9999 | 0.9999 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 22.3872 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.