Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | cytochrome b | 0.0911 | 0.5 | 0.5 |
Plasmodium vivax | cytochrome b | 0.0911 | 0.5 | 0.5 |
Toxoplasma gondii | apocytochrome b, putative | 0.0911 | 0.5 | 0.5 |
Schistosoma mansoni | cytochrome b | 0.0911 | 0.5 | 0.5 |
Echinococcus granulosus | cytochrome B | 0.0911 | 0.5 | 0.5 |
Loa Loa (eye worm) | cytochrome b | 0.0911 | 0.5 | 0.5 |
Plasmodium falciparum | cytochrome b | 0.0911 | 0.5 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | cytochrome b subunit of the bc complex | 0.0911 | 0.5 | 0.5 |
Schistosoma mansoni | cytochrome b | 0.0911 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 43.71 umol/L | Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT based ELISA | ChEMBL. | 21504204 |
IC50 (functional) | > 50 umol/L | Cytotoxicity against human HepG2 cells after 48 hrs by MTT based ELISA | ChEMBL. | 21504204 |
IC50 (functional) | > 50 umol/L | Cytotoxicity against human Bel7402 cells after 48 hrs by MTT based ELISA | ChEMBL. | 21504204 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.