Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | jun protein | 0.0087 | 1 | 1 |
Echinococcus granulosus | nuclear factor of activated T cells 5 | 0.0076 | 0.8512 | 0.8512 |
Schistosoma mansoni | jun-related protein | 0.007 | 0.7736 | 1 |
Echinococcus multilocularis | jun protein | 0.0087 | 1 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.3091 | 0.3091 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.3091 | 0.3996 |
Brugia malayi | hypothetical protein | 0.0068 | 0.7404 | 0.6243 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.3091 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.3091 | 0.3091 |
Schistosoma mansoni | hypothetical protein | 0.007 | 0.7736 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.3091 | 0.5 |
Onchocerca volvulus | 0.0068 | 0.7404 | 0.5 | |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.3091 | 0.5 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0076 | 0.8512 | 0.8512 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.3091 | 0.3996 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.9669 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0087 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.3091 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0087 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 35.82 umol/L | Cytotoxicity against human Bel7402 cells after 48 hrs by MTT based ELISA | ChEMBL. | 21504204 |
IC50 (functional) | = 37.14 umol/L | Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT based ELISA | ChEMBL. | 21504204 |
IC50 (functional) | > 50 umol/L | Cytotoxicity against human HepG2 cells after 48 hrs by MTT based ELISA | ChEMBL. | 21504204 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.