Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.004 | 0.3091 | 0.3091 |
Schistosoma mansoni | hypothetical protein | 0.0076 | 0.7736 | 1 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.3091 | 0.5 |
Brugia malayi | hypothetical protein | 0.0073 | 0.7404 | 0.6243 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.004 | 0.3091 | 0.3091 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.3091 | 0.3996 |
Echinococcus granulosus | nuclear factor of activated T cells 5 | 0.0082 | 0.8512 | 0.8512 |
Echinococcus granulosus | jun protein | 0.0093 | 1 | 1 |
Echinococcus multilocularis | jun protein | 0.0093 | 1 | 1 |
Schistosoma mansoni | jun-related protein | 0.0076 | 0.7736 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0093 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.3091 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0093 | 1 | 1 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0082 | 0.8512 | 0.8512 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.9669 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.004 | 0.3091 | 0.3996 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.3091 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.3091 | 0.5 |
Onchocerca volvulus | 0.0073 | 0.7404 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI (functional) | = 0 % | Cytotoxicity against human A549 cells assessed as cell growth inhibition at 10 uM after 48 hrs by sulforhodamine B assay | ChEMBL. | 21482109 |
GI (functional) | = 48 % | Cytotoxicity against human Hep2 cells assessed as cell growth inhibition at 10 uM after 48 hrs by sulforhodamine B assay | ChEMBL. | 21482109 |
GI (functional) | = 53 % | Cytotoxicity against human A549 cells assessed as cell growth inhibition at 100 uM after 48 hrs by sulforhodamine B assay | ChEMBL. | 21482109 |
GI (functional) | = 67 % | Cytotoxicity against human HCT15 cells assessed as cell growth inhibition at 10 uM after 48 hrs by sulforhodamine B assay | ChEMBL. | 21482109 |
GI (functional) | = 86 % | Cytotoxicity against human Hep2 cells assessed as cell growth inhibition at 100 uM after 48 hrs by sulforhodamine B assay | ChEMBL. | 21482109 |
GI (functional) | = 93 % | Cytotoxicity against human THP1 cells assessed as cell growth inhibition at 100 uM after 48 hrs by sulforhodamine B assay | ChEMBL. | 21482109 |
GI (functional) | = 94 % | Cytotoxicity against human THP1 cells assessed as cell growth inhibition at 10 uM after 48 hrs by sulforhodamine B assay | ChEMBL. | 21482109 |
GI (functional) | = 95 % | Cytotoxicity against human HCT15 cells assessed as cell growth inhibition at 100 uM after 48 hrs by sulforhodamine B assay | ChEMBL. | 21482109 |
IC50 (functional) | = 11.72 uM | Cytotoxicity against human PC3 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 21482109 |
IC50 (functional) | = 11.97 uM | Cytotoxicity against human HeLa cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 21482109 |
IC50 (functional) | = 12.38 uM | Cytotoxicity against human HCT15 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 21482109 |
IC50 (functional) | > 20 uM | Antiplasmodial activity against Plasmodium falciparum W2 | ChEMBL. | 21376591 |
IC50 (functional) | = 26.5 uM | Cytotoxicity against human THP1 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 21482109 |
IC50 (functional) | > 100 uM | Cytotoxicity against human COLO205 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 21482109 |
IC50 (functional) | > 100 uM | Cytotoxicity against human A549 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 21482109 |
Inhibition (functional) | Antitubercular activity against Mycobacterium tuberculosis H37Rv at 10 ug/ml by BACTEC radiometric susceptibility assay | ChEMBL. | 21376591 | |
Inhibition (functional) | Antitubercular activity against Mycobacterium tuberculosis H37Rv at 1 ug/ml by BACTEC radiometric susceptibility assay | ChEMBL. | 21376591 | |
MIC (functional) | = 97.6 uM | Antitubercular activity against Mycobacterium tuberculosis H37Rv by microplate alamar blue assay | ChEMBL. | 21376591 |
MIC (functional) | = 108 uM | Antitubercular activity against Mycobacterium tuberculosis H37Rv by LORA assay | ChEMBL. | 21376591 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 21482109 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.