Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Onchocerca volvulus | 0.0414 | 0.0531 | 0.5 | |
Schistosoma mansoni | opsin-like receptor | 0.0414 | 0.0531 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0325 | 0.0345 | 0.5 |
Schistosoma mansoni | amine GPCR | 0.0414 | 0.0531 | 0.5 |
Brugia malayi | Dopamine receptor protein 2 | 0.0414 | 0.0531 | 0.5 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0325 | 0.0345 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Brugia malayi | Dopamine receptor protein 1 | 0.0414 | 0.0531 | 0.5 |
Brugia malayi | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0325 | 0.0345 | 0.5 |
Onchocerca volvulus | 0.0414 | 0.0531 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Brugia malayi | neuropeptide F receptor | 0.0414 | 0.0531 | 0.5 |
Brugia malayi | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Brugia malayi | Serotonin receptor | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Brugia malayi | Tachykinin-like peptides receptor 99D | 0.0414 | 0.0531 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0325 | 0.0345 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Brugia malayi | sulfakinin receptor protein | 0.0414 | 0.0531 | 0.5 |
Brugia malayi | Dopamine receptor | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | melatonin receptor type 1A | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.0414 | 0.0531 | 0.5 |
Onchocerca volvulus | 0.0414 | 0.0531 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Brugia malayi | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.0414 | 0.0531 | 0.5 |
Brugia malayi | larval opioid receptor | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | peptide (allatostatin)-like receptor | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | thyrotropin-releasing hormone receptor | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | amine GPCR | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | amine GPCR | 0.0414 | 0.0531 | 0.5 |
Onchocerca volvulus | 0.0414 | 0.0531 | 0.5 | |
Brugia malayi | Dopamine receptor protein 1, putative (partial) | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | amine GPCR | 0.0414 | 0.0531 | 0.5 |
Brugia malayi | G-protein coupled receptor | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | opsin-like receptor | 0.0414 | 0.0531 | 0.5 |
Brugia malayi | follicle stimulating hormone receptor | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | adenoreceptor | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Brugia malayi | G protein-coupled receptor | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | neuropeptide F-like receptor | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | neuropeptide receptor | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | G-protein-linked acetylcholine receptor protein 2 | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | muscarinic acetylcholine (GAR) receptor | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0414 | 0.0531 | 0.5 |
Onchocerca volvulus | 0.0414 | 0.0531 | 0.5 | |
Onchocerca volvulus | 0.0414 | 0.0531 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | neuropeptide receptor | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0414 | 0.0531 | 0.5 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0325 | 0.0345 | 0.5 |
Onchocerca volvulus | 0.0414 | 0.0531 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0414 | 0.0531 | 0.5 |
Onchocerca volvulus | 0.0414 | 0.0531 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0325 | 0.0345 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | amine GPCR | 0.0414 | 0.0531 | 0.5 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0325 | 0.0345 | 0.5 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | TYRA-2 protein | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0414 | 0.0531 | 0.5 |
Brugia malayi | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0325 | 0.0345 | 0.5 |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Brugia malayi | Serotonin receptor | 0.0414 | 0.0531 | 0.5 |
Brugia malayi | Unidentified vitellogenin-linked transcript protein 6, putative | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | 5-hydroxytryptamine 2C receptor | 0.0414 | 0.0531 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0325 | 0.0345 | 0.5 |
Brugia malayi | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Brugia malayi | putative neuropeptide receptor | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | growth hormone secretagogue receptor | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0414 | 0.0531 | 0.5 |
Brugia malayi | RE15519p | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Brugia malayi | G protein-coupled receptor F59B2.13 | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0414 | 0.0531 | 0.5 |
Brugia malayi | neuropeptide F receptor | 0.0414 | 0.0531 | 0.5 |
Onchocerca volvulus | 0.0414 | 0.0531 | 0.5 | |
Onchocerca volvulus | 0.0414 | 0.0531 | 0.5 | |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0414 | 0.0531 | 0.5 |
Mycobacterium leprae | Probable anthranilate phosphoribosyltransferase TrpD | 0.1403 | 0.2586 | 1 |
Brugia malayi | gonadotropin-releasing hormone receptor 2 | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0414 | 0.0531 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0325 | 0.0345 | 0.5 |
Schistosoma mansoni | alpha-1 adrenergic receptor | 0.0414 | 0.0531 | 0.5 |
Mycobacterium tuberculosis | Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) | 0.4969 | 1 | 1 |
Schistosoma mansoni | neuropeptide f receptor 76f | 0.0414 | 0.0531 | 0.5 |
Onchocerca volvulus | 0.0414 | 0.0531 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | opsin-like receptor | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | biogenic amine receptor | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | neuropeptide receptor | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Onchocerca volvulus | 0.0414 | 0.0531 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | peptide (allatostatin/somatostatin)-like receptor | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | histamine-responsive GPCR (AAF21638) | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | myosin xvIII | 0.0414 | 0.0531 | 0.5 |
Brugia malayi | AKH receptor | 0.0414 | 0.0531 | 0.5 |
Brugia malayi | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Onchocerca volvulus | 0.0414 | 0.0531 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Brugia malayi | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0325 | 0.0345 | 0.5 |
Brugia malayi | ORL1-like opioid receptor | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | neuropeptide F-like receptor | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | biogenic amine receptor | 0.0414 | 0.0531 | 0.5 |
Onchocerca volvulus | 0.0414 | 0.0531 | 0.5 | |
Brugia malayi | GnHR receptor homolog | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Brugia malayi | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Brugia malayi | G-protein-linked acetylcholine receptor protein 2, putative | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | peptide (FMRFamide/neurokinin-3)-like receptor | 0.0414 | 0.0531 | 0.5 |
Mycobacterium tuberculosis | Probable anthranilate phosphoribosyltransferase TrpD | 0.1403 | 0.2586 | 0.2586 |
Onchocerca volvulus | 0.0414 | 0.0531 | 0.5 | |
Schistosoma mansoni | neuropeptide receptor | 0.0414 | 0.0531 | 0.5 |
Mycobacterium ulcerans | thymidine phosphorylase | 0.4969 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Brugia malayi | G-protein coupled receptor | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | ancient conserved domain protein 2 (cyclin m2) | 0.0414 | 0.0531 | 0.5 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0325 | 0.0345 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Onchocerca volvulus | 0.0414 | 0.0531 | 0.5 | |
Schistosoma mansoni | biogenic amine receptor | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Brugia malayi | Melatonin receptor type 1A | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | unidentified vitellogenin-linked transcript protein 6 | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | gonadotropin-releasing hormone receptor 2 | 0.0414 | 0.0531 | 0.5 |
Echinococcus multilocularis | thymidine phosphorylase | 0.4969 | 1 | 1 |
Brugia malayi | putative neuropeptide receptor NPR1 | 0.0414 | 0.0531 | 0.5 |
Schistosoma mansoni | histamine h1 receptor | 0.0414 | 0.0531 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.0531 | 0.5 |
Mycobacterium ulcerans | anthranilate phosphoribosyltransferase | 0.1403 | 0.2586 | 0.2586 |
Onchocerca volvulus | 0.0414 | 0.0531 | 0.5 | |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0414 | 0.0531 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference | |
AC50 (functional) | PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.