Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | TAR-binding protein | 0.0061 | 0.346 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0 | 0.5 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.346 | 0.346 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0018 | 0 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0 | 0.5 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0018 | 0 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0061 | 0.346 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0061 | 0.346 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.0018 | 0 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0 | 0.5 |
Brugia malayi | RNA binding protein | 0.0061 | 0.346 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0061 | 0.346 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0061 | 0.346 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.346 | 0.346 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.346 | 0.346 |
Brugia malayi | TAR-binding protein | 0.0061 | 0.346 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0061 | 0.346 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.346 | 0.346 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0 | 0.5 |
Trypanosoma brucei | RNA helicase, putative | 0.0143 | 1 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.346 | 0.346 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.