Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | histone deacetylase 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma cruzi | histone deacetylase, putative | histone deacetylase 3 | 428 aa | 374 aa | 30.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0461 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.1961 | 0.7602 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0077 | 0.0604 | 0.5 |
Trypanosoma brucei | histone deacetylase 1 | 0.0077 | 0.0604 | 0.5 |
Plasmodium falciparum | histone deacetylase 1 | 0.0077 | 0.0604 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0461 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0077 | 0.0604 | 0.5 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0077 | 0.0604 | 0.0184 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0077 | 0.0604 | 0.5 |
Leishmania major | histone deacetylase, putative | 0.0077 | 0.0604 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0077 | 0.0604 | 0.5 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.0077 | 0.0604 | 0.0184 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.1946 | 0.752 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0202 | 0.3664 | 0.3381 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0077 | 0.0604 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0461 | 1 | 1 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0077 | 0.0604 | 0.5 |
Leishmania major | histone deacetylase, putative | 0.0077 | 0.0604 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0077 | 0.0604 | 0.5 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0077 | 0.0604 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0461 | 1 | 1 |
Echinococcus granulosus | aryl hydrocarbon receptor | 0.015 | 0.2404 | 0.1915 |
Schistosoma mansoni | hypothetical protein | 0.0461 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0077 | 0.0604 | 0.5 |
Onchocerca volvulus | 0.015 | 0.2389 | 1 | |
Brugia malayi | Histone deacetylase 1 | 0.0077 | 0.0604 | 0.0184 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0077 | 0.0604 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0461 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0077 | 0.0604 | 0.5 |
Echinococcus multilocularis | aryl hydrocarbon receptor | 0.015 | 0.2404 | 0.1915 |
Schistosoma mansoni | histone deacetylase | 0.0077 | 0.0604 | 0.0184 |
Schistosoma mansoni | histone deacetylase | 0.0077 | 0.0604 | 0.0184 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.2389 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0077 | 0.0604 | 0.5 |
Brugia malayi | aryl hydrocarbon receptor AHR-1 | 0.0132 | 0.1946 | 0.1586 |
Giardia lamblia | Histone deacetylase | 0.0077 | 0.0604 | 0.5 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0077 | 0.0604 | 0.5 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0077 | 0.0604 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0461 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0461 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 18.4 uM | Inhibition of human HDAC3 using ArgHisLysLys(Ac) fluorogenic peptide as a substrate by fluorimetric assay | ChEMBL. | 21417297 |
IC50 (binding) | = 32.1 uM | Inhibition of human HDAC9 using ArgHisLysLys(Ac) fluorogenic peptide as a substrate by fluorimetric assay | ChEMBL. | 21417297 |
IC50 (binding) | = 42.8 uM | Inhibition of human HDAC7 using ArgHisLysLys(Ac) fluorogenic peptide as a substrate by fluorimetric assay | ChEMBL. | 21417297 |
IC50 (binding) | = 76.7 uM | Inhibition of human HDAC8 using ArgHisLysLys(Ac) fluorogenic peptide as a substrate by fluorimetric assay | ChEMBL. | 21417297 |
IC50 (binding) | > 100 uM | Inhibition of human HDAC1 using ArgHisLysLys(Ac) fluorogenic peptide as a substrate by fluorimetric assay | ChEMBL. | 21417297 |
IC50 (binding) | > 100 uM | Inhibition of human HDAC2 using ArgHisLysLys(Ac) fluorogenic peptide as a substrate by fluorimetric assay | ChEMBL. | 21417297 |
IC50 (binding) | > 100 uM | Inhibition of human HDAC4 using ArgHisLysLys(Ac) fluorogenic peptide as a substrate by fluorimetric assay | ChEMBL. | 21417297 |
IC50 (binding) | > 100 uM | Inhibition of human HDAC5 using ArgHisLysLys(Ac) fluorogenic peptide as a substrate by fluorimetric assay | ChEMBL. | 21417297 |
IC50 (binding) | > 100 uM | Inhibition of human HDAC6 using ArgHisLysLys(Ac) fluorogenic peptide as a substrate by fluorimetric assay | ChEMBL. | 21417297 |
IC50 (binding) | > 100 uM | Inhibition of human HDAC10 using ArgHisLysLys(Ac) fluorogenic peptide as a substrate by fluorimetric assay | ChEMBL. | 21417297 |
IC50 (binding) | > 100 uM | Inhibition of human HDAC11 using ArgHisLysLys(Ac) fluorogenic peptide as a substrate by fluorimetric assay | ChEMBL. | 21417297 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.