Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | purinergic receptor P2Y, G-protein coupled, 12 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.1427 | 0.1427 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0771 | 0.654 | 0.713 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0449 | 0.346 | 0.3772 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0236 | 0.1427 | 0.1427 |
Schistosoma mansoni | hypothetical protein | 0.0149 | 0.0601 | 0.0655 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0236 | 0.1427 | 0.1792 |
Brugia malayi | metabotropic GABA-B receptor subtype 2 | 0.0149 | 0.0601 | 0.0754 |
Loa Loa (eye worm) | hypothetical protein | 0.1134 | 1 | 1 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0771 | 0.654 | 0.654 |
Loa Loa (eye worm) | glutamate receptor | 0.0921 | 0.7968 | 0.7968 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0834 | 0.7141 | 0.8962 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.1134 | 1 | 1 |
Loa Loa (eye worm) | glutamate receptor | 0.0362 | 0.2633 | 0.2633 |
Entamoeba histolytica | hypothetical protein | 0.0087 | 0 | 0.5 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.1047 | 0.9173 | 1 |
Echinococcus multilocularis | GPCR, family 3, C terminal | 0.0149 | 0.0601 | 0.0601 |
Echinococcus granulosus | GPCR family 3 C terminal | 0.0149 | 0.0601 | 0.0601 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0921 | 0.7968 | 1 |
Onchocerca volvulus | Poor gastrulation protein homolog | 0.0149 | 0.0601 | 1 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0771 | 0.654 | 0.654 |
Trypanosoma cruzi | extracellular receptor, putative | 0.0087 | 0 | 0.5 |
Leishmania major | extracellular receptor, putative | 0.0087 | 0 | 0.5 |
Onchocerca volvulus | Metabotropic glutamate receptor homolog | 0.0149 | 0.0601 | 1 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0236 | 0.1427 | 0.1427 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0449 | 0.346 | 0.4342 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.0601 | 0.0601 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.6 uM | Displacement of [125I]-AZ11931285 from human recombinant P2Y12 receptor expressed in platelet cell membrane after 1 hr by scintillation counting | ChEMBL. | 21507636 |
IC50 (binding) | = 0.6 uM | Displacement of [125I]-AZ11931285 from P2Y12 receptor (unknown origin) after 1 hr by scintillation counting analysis | ChEMBL. | 23747805 |
IC50 (functional) | = 1.1 uM | Antagonist activity at human recombinant P2Y12 receptor expressed in platelet cell membrane by [35S]GTPgammaS binding assay | ChEMBL. | 21507636 |
IC50 (functional) | = 1.1 uM | Antagonist activity at P2Y12 receptor (unknown origin) assessed as inhibition of GTPgammaS binding after 1 hr by scintillation counting analysis | ChEMBL. | 23747805 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.