Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0073 | 0.0081 | 1 |
Trypanosoma brucei | 2OG-Fe(II) oxygenase superfamily, putative | 0.0073 | 0.0081 | 1 |
Trypanosoma brucei | 2OG-Fe(II) oxygenase superfamily, putative | 0.0073 | 0.0081 | 1 |
Onchocerca volvulus | 0.0073 | 0.0081 | 0.5 | |
Echinococcus multilocularis | nucleic acid binding | 0.0073 | 0.0081 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0073 | 0.0081 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0073 | 0.0081 | 1 |
Trypanosoma cruzi | 2OG-Fe(II) oxygenase superfamily, putative | 0.0073 | 0.0081 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0 | 0.5 |
Brugia malayi | ALKBH protein | 0.0073 | 0.0081 | 1 |
Onchocerca volvulus | 0.0073 | 0.0081 | 0.5 | |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0 | 0.5 |
Echinococcus granulosus | nucleic acid binding | 0.0073 | 0.0081 | 0.5 |
Onchocerca volvulus | Alkylated DNA repair protein alkB homolog | 0.0073 | 0.0081 | 0.5 |
Loa Loa (eye worm) | ALKBH protein | 0.0073 | 0.0081 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0073 | 0.0081 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0073 | 0.0081 | 1 |
Echinococcus multilocularis | conserved hypothetical protein | 0.0073 | 0.0081 | 0.5 |
Trypanosoma brucei | 2OG-Fe(II) oxygenase superfamily, putative | 0.0073 | 0.0081 | 1 |
Trypanosoma brucei | 2OG-Fe(II) oxygenase superfamily, putative | 0.0073 | 0.0081 | 1 |
Trypanosoma cruzi | 2OG-Fe(II) oxygenase superfamily, putative | 0.0073 | 0.0081 | 1 |
Schistosoma mansoni | nucleic acid binding | 0.0073 | 0.0081 | 0.5 |
Trypanosoma brucei | Alkylated DNA repair protein (alkB homolog), putative | 0.0073 | 0.0081 | 1 |
Trypanosoma cruzi | 2OG-Fe(II) oxygenase superfamily, putative | 0.0073 | 0.0081 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.5297 | 1 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.5297 | 1 | 0.5 |
Trypanosoma brucei | 2OG-Fe(II) oxygenase superfamily, putative | 0.0073 | 0.0081 | 1 |
Echinococcus granulosus | alkylated DNA repair protein alkB | 0.0073 | 0.0081 | 0.5 |
Trypanosoma cruzi | alkylated DNA repair protein, putative | 0.0073 | 0.0081 | 1 |
Trypanosoma cruzi | 2OG-Fe(II) oxygenase superfamily, putative | 0.0073 | 0.0081 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0073 | 0.0081 | 0.5 |
Brugia malayi | spermatogenesis associated 11 | 0.0073 | 0.0081 | 1 |
Loa Loa (eye worm) | spermatogenesis associated 11 | 0.0073 | 0.0081 | 1 |
Schistosoma mansoni | nucleic acid binding | 0.0073 | 0.0081 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0073 | 0.0081 | 1 |
Trypanosoma cruzi | 2OG-Fe(II) oxygenase superfamily, putative | 0.0073 | 0.0081 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0081 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0081 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.8913 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.9185 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.