Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | bradykinin receptor B1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0099 | 0 | 0.5 | |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0174 | 0.5386 | 0.6119 |
Echinococcus granulosus | bromodomain containing 2 | 0.0222 | 0.8802 | 0.7404 |
Brugia malayi | Bromodomain containing protein | 0.0222 | 0.8802 | 0.9211 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0226 | 0.9095 | 1 |
Echinococcus multilocularis | histone deacetylase | 0.0226 | 0.9095 | 0.9095 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0174 | 0.5386 | 0.5386 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0174 | 0.5386 | 0.6119 |
Loa Loa (eye worm) | histone deacetylase | 0.0226 | 0.9095 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.4216 | 0.4636 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0238 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0174 | 0.5386 | 0.6119 |
Echinococcus granulosus | histone deacetylase 6 | 0.0226 | 0.9095 | 0.8038 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0138 | 0.2784 | 0.3163 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0174 | 0.5386 | 0.5922 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0174 | 0.5386 | 0.6119 |
Brugia malayi | Histone deacetylase family protein | 0.0226 | 0.9095 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.5386 | 0.5922 |
Echinococcus granulosus | histone deacetylase 6 | 0.0226 | 0.9095 | 0.8038 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0138 | 0.2784 | 0.3163 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0226 | 0.9095 | 0.9095 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0138 | 0.2784 | 0.3163 |
Brugia malayi | Histone deacetylase family protein | 0.0226 | 0.9095 | 1 |
Trypanosoma brucei | histone deacetylase 3 | 0.0226 | 0.9095 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0226 | 0.9095 | 1 |
Schistosoma mansoni | bromodomain-containing protein 3 brd3 | 0.0222 | 0.8802 | 0.7404 |
Plasmodium vivax | histone deacetylase, putative | 0.0226 | 0.9095 | 1 |
Giardia lamblia | Histone deacetylase | 0.0174 | 0.5386 | 1 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0226 | 0.9095 | 0.8038 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0174 | 0.5386 | 0.5922 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0174 | 0.5386 | 0.6119 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0174 | 0.5386 | 0.5922 |
Leishmania major | histone deacetylase, putative | 0.0226 | 0.9095 | 1 |
Trypanosoma brucei | histone deacetylase, putative | 0.0226 | 0.9095 | 1 |
Leishmania major | histone deacetylase, putative | 0.0226 | 0.9095 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0226 | 0.9095 | 1 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0226 | 0.9095 | 0.9095 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0123 | 0.1729 | 0.1964 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0174 | 0.5386 | 0.5922 |
Trichomonas vaginalis | bromodomain containing protein, putative | 0.0138 | 0.2784 | 0.3163 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0174 | 0.5386 | 0.6119 |
Echinococcus granulosus | histone deacetylase 7 | 0.0226 | 0.9095 | 0.8038 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0226 | 0.9095 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0226 | 0.9095 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.3311 | 0.364 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0222 | 0.8802 | 1 |
Plasmodium falciparum | histone deacetylase, putative | 0.0226 | 0.9095 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0222 | 0.8802 | 0.9678 |
Trypanosoma brucei | histone deacetylase 4 | 0.0226 | 0.9095 | 1 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0226 | 0.9095 | 0.8038 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0222 | 0.8802 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0174 | 0.5386 | 0.6119 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0226 | 0.9095 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0174 | 0.5386 | 0.6119 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0174 | 0.5386 | 0.6119 |
Brugia malayi | Bromodomain containing protein | 0.0222 | 0.8802 | 0.9211 |
Entamoeba histolytica | histone deacetylase, putative | 0.0174 | 0.5386 | 1 |
Plasmodium falciparum | histone deacetylase 2 | 0.0226 | 0.9095 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0226 | 0.9095 | 0.9095 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0238 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0174 | 0.5386 | 0.5386 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0138 | 0.2784 | 0.3163 |
Echinococcus granulosus | histone deacetylase | 0.0226 | 0.9095 | 0.8038 |
Echinococcus multilocularis | bromodomain containing 2 | 0.0222 | 0.8802 | 0.8802 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1.2 nM | Antagonist activity at human bradykinin B1 receptor expressed in CHO cells assessed as inhibition of agonist-induced calcium efflux by aquerin based assay | ChEMBL. | 21514825 |
Ki (functional) | = 3 nM | Antagonist activity at human bradykinin B1 receptor | ChEMBL. | 21514825 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.