Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | diacylglycerol O acyltransferase 1 | 0.539 | 1 | 0.5 |
Schistosoma mansoni | diacylglycerol O-acyltransferase 1 | 0.539 | 1 | 0.5 |
Plasmodium vivax | diacylglycerol O-acyltransferase, putative | 0.539 | 1 | 0.5 |
Toxoplasma gondii | acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha | 0.539 | 1 | 0.5 |
Toxoplasma gondii | acyl-CoA:diacylglycerol acyltransferase 1-related enzyme | 0.539 | 1 | 0.5 |
Plasmodium falciparum | diacylglycerol O-acyltransferase | 0.539 | 1 | 0.5 |
Echinococcus multilocularis | diacylglycerol O acyltransferase 1 | 0.539 | 1 | 0.5 |
Loa Loa (eye worm) | diacylglycerol acyltransferase | 0.539 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 1.8 ug ml-1 | Antimicrobial activity against Escherichia coli K12D31 by microdilution assay | ChEMBL. | 19546372 |
MIC (functional) | = 2 ug ml-1 | Antimicrobial activity against Escherichia coli K88 by microdilution assay | ChEMBL. | 19546372 |
MIC (functional) | = 2 ug ml-1 | Antimicrobial activity against Escherichia coli K99 by microdilution assay | ChEMBL. | 19546372 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.