Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0048 | 1 | 0.5 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0042 | 0.7743 | 0.5 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0048 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0024 | 0 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0048 | 1 | 0.5 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0048 | 1 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0048 | 1 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0024 | 0.0151 | 0.0151 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0029 | 0.2407 | 0.2407 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0048 | 1 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0048 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0024 | 0 | 0.5 |
Chlamydia trachomatis | sulfite reductase | 0.0029 | 0.2407 | 0.5 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0048 | 1 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0048 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0042 | 0.7743 | 0.5 |
Trypanosoma cruzi | p450 reductase, putative | 0.0048 | 1 | 0.5 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0048 | 1 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0048 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0048 | 1 | 1 |
Leishmania major | p450 reductase, putative | 0.0048 | 1 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0048 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0048 | 1 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0048 | 1 | 0.5 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0048 | 1 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0048 | 1 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0048 | 1 | 1 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0048 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antifungal activity against Candida albicans ATCC 90028 after 48 hrs by agar diffusion bioautography method | ChEMBL. | 21530273 | |
Activity (functional) | Antifungal activity against Cryptococcus neoformans ATCC 14116 after 72 hrs by agar diffusion bioautography method | ChEMBL. | 21530273 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.