Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | hexokinase | 0.1055 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.072 | 0.5339 | 0.5339 |
Trypanosoma cruzi | hexokinase, putative | 0.1055 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.1055 | 1 | 0.5 |
Plasmodium falciparum | hexokinase | 0.1055 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.1055 | 1 | 0.5 |
Brugia malayi | Hexokinase family protein | 0.0662 | 0.4537 | 0.4537 |
Treponema pallidum | hexokinase (hxk) | 0.1055 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase type II | 0.1055 | 1 | 1 |
Toxoplasma gondii | hexokinase | 0.1055 | 1 | 0.5 |
Trypanosoma cruzi | hexokinase, putative | 0.1055 | 1 | 0.5 |
Entamoeba histolytica | hexokinase 2 | 0.1055 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.1055 | 1 | 1 |
Entamoeba histolytica | hexokinase 1 | 0.1055 | 1 | 0.5 |
Trypanosoma brucei | hexokinase, putative | 0.1055 | 1 | 0.5 |
Onchocerca volvulus | 0.1055 | 1 | 1 | |
Schistosoma mansoni | hexokinase | 0.1055 | 1 | 0.5 |
Leishmania major | hexokinase, putative | 0.1055 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.1055 | 1 | 0.5 |
Plasmodium vivax | hexokinase, putative | 0.1055 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.1055 | 1 | 0.5 |
Trypanosoma brucei | hexokinase | 0.1055 | 1 | 0.5 |
Trypanosoma brucei | hexokinase | 0.1055 | 1 | 0.5 |
Brugia malayi | Hexokinase family protein | 0.1055 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.1055 | 1 | 0.5 |
Leishmania major | hexokinase, putative | 0.1055 | 1 | 0.5 |
Onchocerca volvulus | 0.1055 | 1 | 1 | |
Onchocerca volvulus | 0.1055 | 1 | 1 | |
Loa Loa (eye worm) | hexokinase | 0.0662 | 0.4537 | 0.4537 |
Echinococcus multilocularis | hexokinase type 2 | 0.1055 | 1 | 0.5 |
Echinococcus granulosus | hexokinase type 2 | 0.1055 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.1055 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0026 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 10.3225 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.