Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0776 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.0119 | 0.0198 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.5245 | 0.8703 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.0776 | 0.1282 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0352 | 0.0236 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0021 | 0.0186 | 0.0131 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0776 | 0.1292 |
Brugia malayi | Muscleblind-like protein | 0.0147 | 0.5245 | 0.8728 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.6009 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.5245 | 0.8703 |
Trypanosoma cruzi | cyclic nucleotide phosphodiesterase | 0.0265 | 1 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0021 | 0.0186 | 0.0068 |
Trypanosoma brucei | 3', 5'-cyclic nucleotide phosphodiesterase, putative | 0.0265 | 1 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0186 | 0.1023 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0352 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0021 | 0.0186 | 0.031 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0021 | 0.0186 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0352 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0352 | 0.0236 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.0186 | 1 |
Brugia malayi | hypothetical protein | 0.0166 | 0.6009 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.0186 | 0.0068 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0352 | 0.0236 |
Onchocerca volvulus | 0.0166 | 0.6009 | 0.5 | |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0021 | 0.0186 | 0.5 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0021 | 0.0186 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0021 | 0.0186 | 0.0068 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0776 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0021 | 0.0186 | 0.0131 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0352 | 0.0395 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0147 | 0.5245 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0021 | 0.0186 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0352 | 0.0236 |
Echinococcus multilocularis | muscleblind protein | 0.0147 | 0.5245 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0021 | 0.0186 | 0.1023 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0776 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.0186 | 0.0068 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0776 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.0119 | 0.0198 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0352 | 0.0586 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0776 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0186 | 0.1023 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0021 | 0.0186 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.0186 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0352 | 1 |
Echinococcus granulosus | muscleblind protein | 0.0147 | 0.5245 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0021 | 0.0186 | 0.0114 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0776 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.0776 | 0.1282 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.0352 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 89.1251 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.