Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | polymerase (DNA directed) iota | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | hypothetical protein, conserved | 0.0079 | 0.0082 | 0.5 |
Brugia malayi | spermatogenesis associated 11 | 0.0079 | 0.0082 | 1 |
Onchocerca volvulus | 0.0079 | 0.0082 | 1 | |
Trypanosoma brucei | 2OG-Fe(II) oxygenase superfamily, putative | 0.0079 | 0.0082 | 0.5 |
Echinococcus multilocularis | conserved hypothetical protein | 0.0079 | 0.0082 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0079 | 0.0082 | 0.5 |
Trypanosoma cruzi | 2OG-Fe(II) oxygenase superfamily, putative | 0.0079 | 0.0082 | 0.5 |
Trypanosoma cruzi | 2OG-Fe(II) oxygenase superfamily, putative | 0.0079 | 0.0082 | 0.5 |
Brugia malayi | hypothetical protein | 0.0079 | 0.0082 | 1 |
Echinococcus granulosus | nucleic acid binding | 0.0079 | 0.0082 | 1 |
Loa Loa (eye worm) | spermatogenesis associated 11 | 0.0079 | 0.0082 | 1 |
Trypanosoma brucei | 2OG-Fe(II) oxygenase superfamily, putative | 0.0079 | 0.0082 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.0082 | 1 |
Brugia malayi | ALKBH protein | 0.0079 | 0.0082 | 1 |
Onchocerca volvulus | 0.0079 | 0.0082 | 1 | |
Schistosoma mansoni | nucleic acid binding | 0.0079 | 0.0082 | 1 |
Trypanosoma brucei | Alkylated DNA repair protein (alkB homolog), putative | 0.0079 | 0.0082 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0079 | 0.0082 | 0.5 |
Trypanosoma brucei | 2OG-Fe(II) oxygenase superfamily, putative | 0.0079 | 0.0082 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0079 | 0.0082 | 0.5 |
Trypanosoma cruzi | alkylated DNA repair protein, putative | 0.0079 | 0.0082 | 0.5 |
Onchocerca volvulus | Alkylated DNA repair protein alkB homolog | 0.0079 | 0.0082 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.5767 | 1 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.5767 | 1 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0079 | 0.0082 | 0.5 |
Schistosoma mansoni | nucleic acid binding | 0.0079 | 0.0082 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0079 | 0.0082 | 1 |
Trypanosoma cruzi | 2OG-Fe(II) oxygenase superfamily, putative | 0.0079 | 0.0082 | 0.5 |
Trypanosoma cruzi | 2OG-Fe(II) oxygenase superfamily, putative | 0.0079 | 0.0082 | 0.5 |
Trypanosoma brucei | 2OG-Fe(II) oxygenase superfamily, putative | 0.0079 | 0.0082 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.0082 | 1 |
Trypanosoma brucei | 2OG-Fe(II) oxygenase superfamily, putative | 0.0079 | 0.0082 | 0.5 |
Echinococcus granulosus | alkylated DNA repair protein alkB | 0.0079 | 0.0082 | 1 |
Echinococcus multilocularis | nucleic acid binding | 0.0079 | 0.0082 | 1 |
Trypanosoma cruzi | 2OG-Fe(II) oxygenase superfamily, putative | 0.0079 | 0.0082 | 0.5 |
Loa Loa (eye worm) | ALKBH protein | 0.0079 | 0.0082 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 10 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.