Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | brahma associated protein | 0.0034 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.7544 | 0.5 |
Echinococcus granulosus | Upstream activation factor subunit UAF30 | 0.0034 | 1 | 0.5 |
Schistosoma mansoni | brg-1 associated factor | 0.0034 | 1 | 0.5 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.0034 | 1 | 1 |
Onchocerca volvulus | 0.0034 | 1 | 0.5 | |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.7544 | 0.5 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0034 | 1 | 1 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0034 | 1 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.7544 | 0.5 |
Chlamydia trachomatis | DNA topoisomerase I | 0.0034 | 1 | 0.5 |
Toxoplasma gondii | SWIB/MDM2 domain-containing protein | 0.0034 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 1 | 0.5 |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.0034 | 1 | 1 |
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.0034 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 1 | 0.5 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0034 | 1 | 0.5 |
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.0034 | 1 | 0.5 |
Brugia malayi | brahma associated protein 60 kDa | 0.0034 | 1 | 1 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0034 | 1 | 0.5 |
Chlamydia trachomatis | SWIB complex protein | 0.0034 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 1 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0034 | 1 | 1 |
Echinococcus granulosus | SWI:SNF matrix associated | 0.0034 | 1 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.7544 | 0.5 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0034 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.003 | 0.7544 | 0.7544 |
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.0034 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0034 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.