Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0043 | 0.1631 | 0.1631 |
Echinococcus multilocularis | family S10 non peptidase ue (S10 family) | 0.0176 | 0.8936 | 0.8729 |
Echinococcus granulosus | family S10 non peptidase ue S10 family | 0.0176 | 0.8936 | 0.8729 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0195 | 1 | 1 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S10, putative | 0.0195 | 1 | 1 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0195 | 1 | 1 |
Echinococcus multilocularis | lysosomal protective protein | 0.0195 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1631 | 0.5 |
Trypanosoma cruzi | serine carboxypeptidase (CBP1), putative | 0.0195 | 1 | 1 |
Schistosoma mansoni | family S10 non-peptidase homologue (S10 family) | 0.0195 | 1 | 1 |
Echinococcus granulosus | lysosomal protective protein | 0.0195 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0195 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1631 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1631 | 0.5 |
Leishmania major | serine carboxypeptidase (CBP1), putative,serine peptidase, Clan SC, Family S10 | 0.0195 | 1 | 1 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0195 | 1 | 1 |
Onchocerca volvulus | Uncharacterized serine carboxypeptidase homolog | 0.0195 | 1 | 0.5 |
Trypanosoma cruzi | serine carboxypeptidase (CBP1), putative | 0.0195 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1631 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.1631 | 0.137 |
Schistosoma mansoni | family S10 unassigned peptidase (S10 family) | 0.0195 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.1631 | 0.137 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S10, putative | 0.0195 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.3696 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 18.3564 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.