Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | euchromatic histone-lysine N-methyltransferase 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Onchocerca volvulus | Get druggable targets OG5_131470 | All targets in OG5_131470 | |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | Get druggable targets OG5_131470 | All targets in OG5_131470 |
Brugia malayi | Pre-SET motif family protein | Get druggable targets OG5_131470 | All targets in OG5_131470 |
Trichomonas vaginalis | set domain proteins, putative | Get druggable targets OG5_131470 | All targets in OG5_131470 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0068 | 0.1271 | 0.5 |
Trichomonas vaginalis | set domain proteins, putative | 0.0286 | 1 | 1 |
Schistosoma mansoni | family M1 non-peptidase homologue (M01 family) | 0.0044 | 0.0317 | 0.2496 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0317 | 0.0369 |
Brugia malayi | Pre-SET motif family protein | 0.0251 | 0.8611 | 1 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0068 | 0.1271 | 0.1635 |
Brugia malayi | hypothetical protein | 0.0068 | 0.1271 | 0.1476 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0068 | 0.1271 | 0.1635 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0068 | 0.1271 | 1 |
Onchocerca volvulus | 0.0068 | 0.1271 | 0.1271 | |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0036 | 0 | 0.5 |
Echinococcus multilocularis | aminopeptidase N | 0.023 | 0.7775 | 1 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0068 | 0.1271 | 1 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0068 | 0.1271 | 0.1635 |
Loa Loa (eye worm) | aminopeptidase N | 0.0068 | 0.1271 | 0.1476 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0068 | 0.1271 | 0.1635 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0317 | 0.0369 |
Entamoeba histolytica | aminopeptidase, putative | 0.0068 | 0.1271 | 0.5 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0186 | 0.6016 | 0.6986 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0068 | 0.1271 | 0.1635 |
Echinococcus multilocularis | Peptidase M1, membrane alanine aminopeptidase, N terminal | 0.0068 | 0.1271 | 0.1635 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0068 | 0.1271 | 0.5 |
Plasmodium vivax | SET domain protein, putative | 0.0036 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 0.6821 | 0.7922 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0251 | 0.8611 | 1 |
Brugia malayi | Peptidase family M1 containing protein | 0.023 | 0.7775 | 0.9029 |
Onchocerca volvulus | 0.023 | 0.7775 | 0.7775 | |
Brugia malayi | Peptidase family M1 containing protein | 0.0068 | 0.1271 | 0.1476 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0068 | 0.1271 | 1 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0068 | 0.1271 | 0.1635 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0068 | 0.1271 | 0.5 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0068 | 0.1271 | 0.1635 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0068 | 0.1271 | 1 |
Echinococcus granulosus | aminopeptidase N | 0.023 | 0.7775 | 1 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0068 | 0.1271 | 0.5 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0068 | 0.1271 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.5062 | 0.5879 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0068 | 0.1271 | 0.5 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0068 | 0.1271 | 0.1635 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0068 | 0.1271 | 0.1635 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0044 | 0.0317 | 0.0408 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0068 | 0.1271 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0029 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 1.7783 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.