Detailed information for compound 153459

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 797.891 | Formula: C47H47N3O9
  • H donors: 1 H acceptors: 6 LogP: 6.13 Rotable bonds: 19
    Rule of 5 violations (Lipinski): 2
  • SMILES: N#Cc1ccc(cc1)[C@H]1OC[C@H]([C@H](O1)c1cccnc1)C/C=C\CCC(=O)OCCOC(=O)CC/C=C\C[C@@H]1CO[C@@H](O[C@@H]1c1ccccc1O)c1ccc(cc1)C#N
  • InChi: 1S/C47H47N3O9/c48-28-33-17-21-35(22-18-33)46-56-31-38(44(58-46)37-12-9-25-50-30-37)10-3-1-5-15-42(52)54-26-27-55-43(53)16-6-2-4-11-39-32-57-47(36-23-19-34(29-49)20-24-36)59-45(39)40-13-7-8-14-41(40)51/h1-4,7-9,12-14,17-25,30,38-39,44-47,51H,5-6,10-11,15-16,26-27,31-32H2/b3-1-,4-2-/t38-,39-,44-,45+,46+,47+/m1/s1
  • InChiKey: TZTAYBMKFYSPIP-XSCIEUTISA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens thromboxane A2 receptor Starlite/ChEMBL No references
Homo sapiens thromboxane A synthase 1 (platelet) Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei cytochrome P450, putative thromboxane A synthase 1 (platelet) 534 aa 498 aa 21.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis somatostatin receptor 0.0112 0.252 1
Echinococcus multilocularis serotonin receptor 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0112 0.252 1
Trichomonas vaginalis aldo/keto reductase, putative 0.0018 0 0.5
Schistosoma mansoni opsin-like receptor 0.0112 0.252 1
Schistosoma mansoni histamine h1 receptor 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0112 0.252 1
Echinococcus granulosus neuropeptide receptor 0.0112 0.252 1
Echinococcus granulosus fmrfamide receptor 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Brugia malayi G-protein coupled receptor 0.0112 0.252 1
Brugia malayi hypothetical protein 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0112 0.252 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0112 0.252 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0112 0.252 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0112 0.252 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0112 0.252 1
Echinococcus granulosus allatostatin A receptor 0.0112 0.252 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0112 0.252 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0112 0.252 1
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0018 0 0.5
Mycobacterium tuberculosis Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) 0.0392 1 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0112 0.252 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0112 0.252 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0112 0.252 1
Brugia malayi neuropeptide F receptor 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Onchocerca volvulus 0.0112 0.252 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0112 0.252 1
Brugia malayi GnHR receptor homolog 0.0112 0.252 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0018 0 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0112 0.252 1
Schistosoma mansoni myosin xvIII 0.0112 0.252 1
Entamoeba histolytica aldose reductase, putative 0.0018 0 0.5
Brugia malayi neuropeptide F receptor 0.0112 0.252 1
Schistosoma mansoni opsin-like receptor 0.0112 0.252 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0112 0.252 1
Brugia malayi Dopamine receptor protein 1 0.0112 0.252 1
Onchocerca volvulus 0.0112 0.252 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0112 0.252 1
Mycobacterium ulcerans isocitrate lyase Icl 0.0392 1 1
Onchocerca volvulus 0.0112 0.252 1
Brugia malayi Serotonin receptor 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Echinococcus multilocularis neuropeptide Y receptor 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Entamoeba histolytica aldose reductase, putative 0.0018 0 0.5
Onchocerca volvulus 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0112 0.252 1
Brugia malayi Dopamine receptor 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0112 0.252 1
Brugia malayi hypothetical protein 0.0112 0.252 1
Echinococcus granulosus tm gpcr rhodopsin 0.0112 0.252 1
Brugia malayi hypothetical protein 0.0112 0.252 1
Echinococcus granulosus neuropeptide Y receptor 0.0112 0.252 1
Echinococcus granulosus g protein coupled receptor 0.0112 0.252 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0112 0.252 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0112 0.252 1
Brugia malayi hypothetical protein 0.0112 0.252 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0112 0.252 1
Mycobacterium ulcerans isocitrate lyase AceAb 0.0392 1 1
Onchocerca volvulus 0.0112 0.252 1
Echinococcus multilocularis neuropeptide receptor 0.0112 0.252 1
Trypanosoma brucei aldo-keto reductase, putative 0.0018 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Brugia malayi Serotonin receptor 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0112 0.252 1
Mycobacterium tuberculosis Isocitrate lyase Icl (isocitrase) (isocitratase) 0.0392 1 1
Onchocerca volvulus 0.0112 0.252 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0112 0.252 1
Brugia malayi hypothetical protein 0.0112 0.252 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0112 0.252 1
Brugia malayi G-protein coupled receptor 0.0112 0.252 1
Echinococcus granulosus somatostatin receptor 0.0112 0.252 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0112 0.252 1
Brugia malayi G protein-coupled receptor 0.0112 0.252 1
Trichomonas vaginalis aldo/keto reductase, putative 0.0018 0 0.5
Loa Loa (eye worm) melatonin receptor type 1A 0.0112 0.252 1
Schistosoma mansoni neuropeptide receptor 0.0112 0.252 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Brugia malayi putative neuropeptide receptor NPR1 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0112 0.252 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Loa Loa (eye worm) neuropeptide F receptor 0.0112 0.252 1
Echinococcus granulosus hypothetical protein 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0112 0.252 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0112 0.252 1
Echinococcus multilocularis sex peptide receptor 0.0112 0.252 1
Echinococcus multilocularis neuropeptides capa receptor 0.0112 0.252 1
Echinococcus multilocularis g protein coupled receptor 0.0112 0.252 1
Echinococcus granulosus g-protein coupled receptor 0.0112 0.252 1
Schistosoma mansoni amine GPCR 0.0112 0.252 1
Giardia lamblia Aldose reductase 0.0018 0 0.5
Trichomonas vaginalis aldo-keto reductase, putative 0.0018 0 0.5
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0018 0 0.5
Brugia malayi hypothetical protein 0.0112 0.252 1
Schistosoma mansoni hypothetical protein 0.0112 0.252 1
Onchocerca volvulus 0.0112 0.252 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0112 0.252 1
Echinococcus granulosus g protein coupled receptor 0.0112 0.252 1
Brugia malayi hypothetical protein 0.0112 0.252 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0112 0.252 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Onchocerca volvulus 0.0112 0.252 1
Echinococcus granulosus tm gpcr rhodopsin 0.0112 0.252 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0112 0.252 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0112 0.252 1
Echinococcus multilocularis g protein coupled receptor 0.0112 0.252 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0112 0.252 1
Brugia malayi sulfakinin receptor protein 0.0112 0.252 1
Echinococcus multilocularis allatostatin A receptor 0.0112 0.252 1
Schistosoma mansoni neuropeptide receptor 0.0112 0.252 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0112 0.252 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0112 0.252 1
Onchocerca volvulus 0.0112 0.252 1
Loa Loa (eye worm) G-protein coupled receptor 0.0112 0.252 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0112 0.252 1
Echinococcus multilocularis neuropeptide Y receptor 0.0112 0.252 1
Echinococcus granulosus neuropeptides capa receptor 0.0112 0.252 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0112 0.252 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0112 0.252 1
Echinococcus multilocularis serotonin receptor 0.0112 0.252 1
Schistosoma mansoni biogenic amine receptor 0.0112 0.252 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Echinococcus granulosus neuropeptide receptor A26 0.0112 0.252 1
Echinococcus multilocularis G protein coupled receptor 139 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Trypanosoma cruzi aldo-keto reductase 0.0018 0 0.5
Echinococcus multilocularis neuropeptide FF receptor 2 0.0112 0.252 1
Echinococcus multilocularis orexin receptor type 2 0.0112 0.252 1
Echinococcus multilocularis neuropeptide receptor A26 0.0112 0.252 1
Brugia malayi putative neuropeptide receptor 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0112 0.252 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0018 0 0.5
Brugia malayi Melatonin receptor type 1A 0.0112 0.252 1
Schistosoma mansoni hypothetical protein 0.0112 0.252 1
Trypanosoma cruzi aldo/keto reductase, putative 0.0018 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Onchocerca volvulus 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Echinococcus granulosus G protein coupled receptor 139 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0112 0.252 1
Echinococcus multilocularis neuropeptides capa receptor 0.0112 0.252 1
Echinococcus granulosus dro:myosuppressin receptor 0.0112 0.252 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0112 0.252 1
Schistosoma mansoni neuropeptide receptor 0.0112 0.252 1
Echinococcus granulosus tm gpcr rhodopsin 0.0112 0.252 1
Echinococcus granulosus neuropeptide s receptor 0.0112 0.252 1
Brugia malayi RE15519p 0.0112 0.252 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0018 0 0.5
Echinococcus granulosus biogenic amine 5HT receptor 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Entamoeba histolytica aldose reductase, putative 0.0018 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Echinococcus multilocularis fmrfamide receptor 0.0112 0.252 1
Schistosoma mansoni hypothetical protein 0.0112 0.252 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0112 0.252 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0112 0.252 1
Echinococcus granulosus neuropeptide receptor 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0112 0.252 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0112 0.252 1
Echinococcus granulosus g protein coupled receptor 0.0112 0.252 1
Giardia lamblia Aldose reductase 0.0018 0 0.5
Mycobacterium tuberculosis Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) 0.0392 1 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0112 0.252 1
Schistosoma mansoni amine GPCR 0.0112 0.252 1
Brugia malayi AKH receptor 0.0112 0.252 1
Echinococcus multilocularis neuropeptide s receptor 0.0112 0.252 1
Brugia malayi Dopamine receptor protein 2 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0018 0 0.5
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0018 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0112 0.252 1
Echinococcus multilocularis g-protein coupled receptor 0.0112 0.252 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0112 0.252 1
Echinococcus granulosus neuropeptides capa receptor 0.0112 0.252 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0112 0.252 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Schistosoma mansoni neuropeptide F-like receptor 0.0112 0.252 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0112 0.252 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0018 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Echinococcus granulosus serotonin receptor 0.0112 0.252 1
Schistosoma mansoni neuropeptide F-like receptor 0.0112 0.252 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0112 0.252 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Schistosoma mansoni biogenic amine receptor 0.0112 0.252 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0112 0.252 1
Brugia malayi hypothetical protein 0.0112 0.252 1
Schistosoma mansoni adenoreceptor 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Brugia malayi hypothetical protein 0.0112 0.252 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0112 0.252 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0112 0.252 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0018 0 0.5
Onchocerca volvulus Neuropeptide F receptor homolog 0.0112 0.252 1
Brugia malayi hypothetical protein 0.0112 0.252 1
Onchocerca volvulus 0.0112 0.252 1
Loa Loa (eye worm) G-protein coupled receptor 0.0112 0.252 1
Schistosoma mansoni amine GPCR 0.0112 0.252 1
Loa Loa (eye worm) TYRA-2 protein 0.0112 0.252 1
Echinococcus multilocularis neuropeptide receptor 0.0112 0.252 1
Brugia malayi ORL1-like opioid receptor 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0112 0.252 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0018 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0112 0.252 1
Onchocerca volvulus 0.0112 0.252 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0112 0.252 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0018 0 0.5
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0112 0.252 1
Onchocerca volvulus 0.0112 0.252 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0112 0.252 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0018 0 0.5
Brugia malayi follicle stimulating hormone receptor 0.0112 0.252 1
Onchocerca volvulus 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0112 0.252 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0112 0.252 1
Onchocerca volvulus 0.0112 0.252 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0018 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Trypanosoma brucei prostaglandin f synthase 0.0018 0 0.5
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0112 0.252 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0112 0.252 1
Loa Loa (eye worm) neuropeptide F receptor 0.0112 0.252 1
Echinococcus multilocularis fmrfamide receptor 0.0112 0.252 1
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0018 0 0.5
Echinococcus granulosus neuropeptide Y receptor 0.0112 0.252 1
Schistosoma mansoni neuropeptide receptor 0.0112 0.252 1
Leishmania major aldo-keto reductase-like protein 0.0018 0 0.5
Echinococcus granulosus tachykinin peptides receptor 99D 0.0112 0.252 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0112 0.252 1
Leishmania major prostaglandin f synthase, putative 0.0018 0 0.5
Trichomonas vaginalis aldo/keto reductase, putative 0.0018 0 0.5
Schistosoma mansoni biogenic amine (5HT) receptor 0.0112 0.252 1
Schistosoma mansoni amine GPCR 0.0112 0.252 1
Mycobacterium leprae Isocitrate lyase 0.0184 0.4429 0.4429
Schistosoma mansoni amine GPCR 0.0112 0.252 1
Schistosoma mansoni hypothetical protein 0.0112 0.252 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0112 0.252 1
Echinococcus granulosus sex peptide receptor 0.0112 0.252 1
Echinococcus multilocularis g protein coupled receptor 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Brugia malayi larval opioid receptor 0.0112 0.252 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0112 0.252 1
Onchocerca volvulus 0.0112 0.252 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0018 0 0.5
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0112 0.252 1
Toxoplasma gondii aldose reductase, putative 0.0018 0 0.5
Schistosoma mansoni biogenic amine receptor 0.0112 0.252 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0112 0.252 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0112 0.252 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0112 0.252 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0018 0 0.5
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0112 0.252 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0112 0.252 1
Echinococcus granulosus orexin receptor type 2 0.0112 0.252 1
Onchocerca volvulus 0.0112 0.252 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0112 0.252 1
Schistosoma mansoni opsin-like receptor 0.0112 0.252 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 10 uM Compound was tested for thromboxane TXA2 synthase inhibitory activity using human platelet ChEMBL. No reference
IC50 (binding) > 10 uM Compound was tested for thromboxane TXA2 synthase inhibitory activity using human platelet ChEMBL. No reference
Kd (functional) > 5 Thromboxane (TXA2) receptor antagonist activity using human platelet ChEMBL. No reference
pA2 (functional) < 5 Thromboxane (TXA2) receptor antagonist activity using human platelet ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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