Detailed information for compound 153459

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 797.891 | Formula: C47H47N3O9
  • H donors: 1 H acceptors: 6 LogP: 6.13 Rotable bonds: 19
    Rule of 5 violations (Lipinski): 2
  • SMILES: N#Cc1ccc(cc1)[C@H]1OC[C@H]([C@H](O1)c1cccnc1)C/C=C\CCC(=O)OCCOC(=O)CC/C=C\C[C@@H]1CO[C@@H](O[C@@H]1c1ccccc1O)c1ccc(cc1)C#N
  • InChi: 1S/C47H47N3O9/c48-28-33-17-21-35(22-18-33)46-56-31-38(44(58-46)37-12-9-25-50-30-37)10-3-1-5-15-42(52)54-26-27-55-43(53)16-6-2-4-11-39-32-57-47(36-23-19-34(29-49)20-24-36)59-45(39)40-13-7-8-14-41(40)51/h1-4,7-9,12-14,17-25,30,38-39,44-47,51H,5-6,10-11,15-16,26-27,31-32H2/b3-1-,4-2-/t38-,39-,44-,45+,46+,47+/m1/s1
  • InChiKey: TZTAYBMKFYSPIP-XSCIEUTISA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens thromboxane A2 receptor Starlite/ChEMBL No references
Homo sapiens thromboxane A synthase 1 (platelet) Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei cytochrome P450, putative thromboxane A synthase 1 (platelet) 534 aa 498 aa 21.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus dro:myosuppressin receptor 0.0112 0.252 1
Mycobacterium leprae Isocitrate lyase 0.0184 0.4429 0.4429
Mycobacterium tuberculosis Isocitrate lyase Icl (isocitrase) (isocitratase) 0.0392 1 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0112 0.252 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0112 0.252 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0018 0 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Brugia malayi neuropeptide F receptor 0.0112 0.252 1
Echinococcus multilocularis neuropeptide Y receptor 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Trichomonas vaginalis aldo/keto reductase, putative 0.0018 0 0.5
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Schistosoma mansoni hypothetical protein 0.0112 0.252 1
Brugia malayi Serotonin receptor 0.0112 0.252 1
Brugia malayi larval opioid receptor 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0112 0.252 1
Loa Loa (eye worm) G-protein coupled receptor 0.0112 0.252 1
Onchocerca volvulus 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Echinococcus granulosus neuropeptide s receptor 0.0112 0.252 1
Brugia malayi putative neuropeptide receptor 0.0112 0.252 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0112 0.252 1
Schistosoma mansoni hypothetical protein 0.0112 0.252 1
Brugia malayi hypothetical protein 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0112 0.252 1
Echinococcus multilocularis neuropeptide Y receptor 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0112 0.252 1
Schistosoma mansoni neuropeptide F-like receptor 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0112 0.252 1
Giardia lamblia Aldose reductase 0.0018 0 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0112 0.252 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0018 0 0.5
Trichomonas vaginalis aldo-keto reductase, putative 0.0018 0 0.5
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0112 0.252 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0112 0.252 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Echinococcus granulosus neuropeptide receptor A26 0.0112 0.252 1
Leishmania major prostaglandin f synthase, putative 0.0018 0 0.5
Schistosoma mansoni opsin-like receptor 0.0112 0.252 1
Onchocerca volvulus 0.0112 0.252 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0112 0.252 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0112 0.252 1
Brugia malayi hypothetical protein 0.0112 0.252 1
Trypanosoma cruzi aldo-keto reductase 0.0018 0 0.5
Loa Loa (eye worm) melatonin receptor type 1A 0.0112 0.252 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0112 0.252 1
Brugia malayi hypothetical protein 0.0112 0.252 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0112 0.252 1
Echinococcus granulosus neuropeptide Y receptor 0.0112 0.252 1
Echinococcus granulosus g-protein coupled receptor 0.0112 0.252 1
Loa Loa (eye worm) TYRA-2 protein 0.0112 0.252 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0112 0.252 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0112 0.252 1
Echinococcus multilocularis allatostatin A receptor 0.0112 0.252 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0112 0.252 1
Onchocerca volvulus 0.0112 0.252 1
Onchocerca volvulus 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Echinococcus multilocularis neuropeptide receptor 0.0112 0.252 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0112 0.252 1
Echinococcus multilocularis g protein coupled receptor 0.0112 0.252 1
Trypanosoma brucei aldo-keto reductase, putative 0.0018 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Echinococcus granulosus hypothetical protein 0.0112 0.252 1
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0018 0 0.5
Brugia malayi Serotonin receptor 0.0112 0.252 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0112 0.252 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0112 0.252 1
Schistosoma mansoni amine GPCR 0.0112 0.252 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0112 0.252 1
Echinococcus granulosus neuropeptides capa receptor 0.0112 0.252 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0112 0.252 1
Brugia malayi Melatonin receptor type 1A 0.0112 0.252 1
Echinococcus multilocularis neuropeptides capa receptor 0.0112 0.252 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0112 0.252 1
Entamoeba histolytica aldose reductase, putative 0.0018 0 0.5
Trichomonas vaginalis aldo-keto reductase, putative 0.0018 0 0.5
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0112 0.252 1
Echinococcus multilocularis sex peptide receptor 0.0112 0.252 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0112 0.252 1
Echinococcus granulosus allatostatin A receptor 0.0112 0.252 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0112 0.252 1
Brugia malayi hypothetical protein 0.0112 0.252 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0112 0.252 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0112 0.252 1
Brugia malayi ORL1-like opioid receptor 0.0112 0.252 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0112 0.252 1
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0018 0 0.5
Brugia malayi G protein-coupled receptor 0.0112 0.252 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0112 0.252 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0112 0.252 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0112 0.252 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0112 0.252 1
Schistosoma mansoni adenoreceptor 0.0112 0.252 1
Echinococcus multilocularis neuropeptide s receptor 0.0112 0.252 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0112 0.252 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0112 0.252 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0112 0.252 1
Brugia malayi follicle stimulating hormone receptor 0.0112 0.252 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0112 0.252 1
Echinococcus granulosus g protein coupled receptor 0.0112 0.252 1
Trypanosoma brucei prostaglandin f synthase 0.0018 0 0.5
Mycobacterium tuberculosis Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) 0.0392 1 1
Echinococcus multilocularis orexin receptor type 2 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Schistosoma mansoni biogenic amine receptor 0.0112 0.252 1
Schistosoma mansoni neuropeptide receptor 0.0112 0.252 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Schistosoma mansoni amine GPCR 0.0112 0.252 1
Brugia malayi hypothetical protein 0.0112 0.252 1
Schistosoma mansoni opsin-like receptor 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0112 0.252 1
Onchocerca volvulus 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0112 0.252 1
Schistosoma mansoni hypothetical protein 0.0112 0.252 1
Schistosoma mansoni biogenic amine receptor 0.0112 0.252 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0018 0 0.5
Schistosoma mansoni myosin xvIII 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Onchocerca volvulus 0.0112 0.252 1
Brugia malayi AKH receptor 0.0112 0.252 1
Schistosoma mansoni amine GPCR 0.0112 0.252 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0112 0.252 1
Echinococcus granulosus G protein coupled receptor 139 0.0112 0.252 1
Echinococcus granulosus tm gpcr rhodopsin 0.0112 0.252 1
Mycobacterium tuberculosis Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) 0.0392 1 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0112 0.252 1
Echinococcus granulosus tm gpcr rhodopsin 0.0112 0.252 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0112 0.252 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0112 0.252 1
Brugia malayi sulfakinin receptor protein 0.0112 0.252 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0112 0.252 1
Brugia malayi hypothetical protein 0.0112 0.252 1
Echinococcus multilocularis neuropeptide receptor A26 0.0112 0.252 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0112 0.252 1
Echinococcus granulosus neuropeptide receptor 0.0112 0.252 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0112 0.252 1
Schistosoma mansoni neuropeptide receptor 0.0112 0.252 1
Schistosoma mansoni histamine h1 receptor 0.0112 0.252 1
Brugia malayi Dopamine receptor 0.0112 0.252 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0112 0.252 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0112 0.252 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0018 0 0.5
Echinococcus multilocularis g protein coupled receptor 0.0112 0.252 1
Loa Loa (eye worm) neuropeptide F receptor 0.0112 0.252 1
Echinococcus granulosus sex peptide receptor 0.0112 0.252 1
Echinococcus multilocularis neuropeptides capa receptor 0.0112 0.252 1
Schistosoma mansoni opsin-like receptor 0.0112 0.252 1
Brugia malayi hypothetical protein 0.0112 0.252 1
Giardia lamblia Aldose reductase 0.0018 0 0.5
Echinococcus multilocularis neuropeptide receptor 0.0112 0.252 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0018 0 0.5
Brugia malayi putative neuropeptide receptor NPR1 0.0112 0.252 1
Echinococcus multilocularis G protein coupled receptor 139 0.0112 0.252 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Echinococcus multilocularis fmrfamide receptor 0.0112 0.252 1
Onchocerca volvulus 0.0112 0.252 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Leishmania major aldo-keto reductase-like protein 0.0018 0 0.5
Entamoeba histolytica aldose reductase, putative 0.0018 0 0.5
Brugia malayi hypothetical protein 0.0112 0.252 1
Echinococcus multilocularis fmrfamide receptor 0.0112 0.252 1
Echinococcus granulosus tm gpcr rhodopsin 0.0112 0.252 1
Schistosoma mansoni neuropeptide receptor 0.0112 0.252 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0112 0.252 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0112 0.252 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0112 0.252 1
Onchocerca volvulus 0.0112 0.252 1
Echinococcus granulosus g protein coupled receptor 0.0112 0.252 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0112 0.252 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0112 0.252 1
Schistosoma mansoni hypothetical protein 0.0112 0.252 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0112 0.252 1
Brugia malayi G-protein coupled receptor 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Schistosoma mansoni biogenic amine receptor 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0112 0.252 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0112 0.252 1
Schistosoma mansoni amine GPCR 0.0112 0.252 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0112 0.252 1
Schistosoma mansoni neuropeptide F-like receptor 0.0112 0.252 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0112 0.252 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0112 0.252 1
Brugia malayi Dopamine receptor protein 1 0.0112 0.252 1
Echinococcus multilocularis g-protein coupled receptor 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Onchocerca volvulus 0.0112 0.252 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0112 0.252 1
Echinococcus multilocularis serotonin receptor 0.0112 0.252 1
Brugia malayi neuropeptide F receptor 0.0112 0.252 1
Trichomonas vaginalis aldo/keto reductase, putative 0.0018 0 0.5
Brugia malayi hypothetical protein 0.0112 0.252 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0018 0 0.5
Echinococcus granulosus orexin receptor type 2 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0112 0.252 1
Mycobacterium ulcerans isocitrate lyase AceAb 0.0392 1 1
Echinococcus granulosus neuropeptide Y receptor 0.0112 0.252 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0112 0.252 1
Brugia malayi GnHR receptor homolog 0.0112 0.252 1
Onchocerca volvulus 0.0112 0.252 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0018 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0018 0 0.5
Echinococcus granulosus neuropeptide receptor 0.0112 0.252 1
Echinococcus granulosus somatostatin receptor 0.0112 0.252 1
Loa Loa (eye worm) neuropeptide F receptor 0.0112 0.252 1
Brugia malayi RE15519p 0.0112 0.252 1
Echinococcus granulosus fmrfamide receptor 0.0112 0.252 1
Schistosoma mansoni amine GPCR 0.0112 0.252 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0018 0 0.5
Onchocerca volvulus 0.0112 0.252 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0112 0.252 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0112 0.252 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0112 0.252 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0112 0.252 1
Onchocerca volvulus 0.0112 0.252 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0112 0.252 1
Brugia malayi G-protein coupled receptor 0.0112 0.252 1
Entamoeba histolytica aldose reductase, putative 0.0018 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Echinococcus multilocularis somatostatin receptor 0.0112 0.252 1
Echinococcus multilocularis serotonin receptor 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0018 0 0.5
Schistosoma mansoni neuropeptide receptor 0.0112 0.252 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0112 0.252 1
Echinococcus multilocularis g protein coupled receptor 0.0112 0.252 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0112 0.252 1
Onchocerca volvulus 0.0112 0.252 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0018 0 0.5
Echinococcus granulosus g protein coupled receptor 0.0112 0.252 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0112 0.252 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0112 0.252 1
Onchocerca volvulus 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0018 0 0.5
Toxoplasma gondii aldose reductase, putative 0.0018 0 0.5
Brugia malayi Dopamine receptor protein 2 0.0112 0.252 1
Mycobacterium ulcerans isocitrate lyase Icl 0.0392 1 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Trichomonas vaginalis aldo/keto reductase, putative 0.0018 0 0.5
Echinococcus granulosus neuropeptides capa receptor 0.0112 0.252 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0018 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0112 0.252 1
Trypanosoma cruzi aldo/keto reductase, putative 0.0018 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Loa Loa (eye worm) G-protein coupled receptor 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Echinococcus granulosus serotonin receptor 0.0112 0.252 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0112 0.252 1
Onchocerca volvulus 0.0112 0.252 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0112 0.252 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0112 0.252 1
Onchocerca volvulus 0.0112 0.252 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.252 1
Onchocerca volvulus 0.0112 0.252 1
Brugia malayi hypothetical protein 0.0112 0.252 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 10 uM Compound was tested for thromboxane TXA2 synthase inhibitory activity using human platelet ChEMBL. No reference
IC50 (binding) > 10 uM Compound was tested for thromboxane TXA2 synthase inhibitory activity using human platelet ChEMBL. No reference
Kd (functional) > 5 Thromboxane (TXA2) receptor antagonist activity using human platelet ChEMBL. No reference
pA2 (functional) < 5 Thromboxane (TXA2) receptor antagonist activity using human platelet ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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