Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | telomerase reverse transcriptase, putative | 0.0802 | 0.2628 | 1 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.0802 | 0.2628 | 1 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0802 | 0.2628 | 1 |
Giardia lamblia | Telomerase catalytic subunit | 0.0802 | 0.2628 | 0.5 |
Mycobacterium tuberculosis | Probable DNA polymerase I PolA | 0.0125 | 0.029 | 1 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0802 | 0.2628 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0 | 0.5 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0802 | 0.2628 | 1 |
Wolbachia endosymbiont of Brugia malayi | DNA polymerase I | 0.0125 | 0.029 | 0.5 |
Treponema pallidum | DNA polymerase I (polA) | 0.0125 | 0.029 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0066 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0066 | 1 |
Mycobacterium ulcerans | DNA polymerase I | 0.0125 | 0.029 | 1 |
Mycobacterium leprae | PROBABLE DNA POLYMERASE I POLA | 0.0125 | 0.029 | 0.5 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.0802 | 0.2628 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0066 | 0.0091 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.0802 | 0.2628 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0066 | 0.0091 |
Brugia malayi | Telomerase reverse transcriptase | 0.2133 | 0.723 | 1 |
Chlamydia trachomatis | DNA polymerase I | 0.0125 | 0.029 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.3323 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 2.5119 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 2.6169 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.