Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0113 | 0.3656 | 1 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0113 | 0.3656 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0113 | 0.3656 | 0.3656 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0113 | 0.3656 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0113 | 0.3656 | 0.5 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0113 | 0.3656 | 0.3656 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 1 | 1 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0113 | 0.3656 | 0.3656 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0113 | 0.3656 | 0.5 |
Brugia malayi | carbohydrate phosphorylase | 0.0113 | 0.3656 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 1 | 1 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0113 | 0.3656 | 1 |
Schistosoma mansoni | glycogen phosphorylase | 0.0113 | 0.3656 | 0.3656 |
Giardia lamblia | Glycogen phosphorylase | 0.0113 | 0.3656 | 0.5 |
Echinococcus multilocularis | geminin | 0.0174 | 1 | 1 |
Echinococcus granulosus | glycogen phosphorylase | 0.0113 | 0.3656 | 0.3656 |
Schistosoma mansoni | glycogen phosphorylase | 0.0113 | 0.3656 | 0.3656 |
Echinococcus granulosus | glycogen phosphorylase | 0.0113 | 0.3656 | 0.3656 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0113 | 0.3656 | 0.3656 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0113 | 0.3656 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 25.929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.