Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | squalene synthase, putative | 0.0353 | 0.649 | 1 |
Echinococcus granulosus | Squalene phytoene synthase | 0.0168 | 0.1475 | 1 |
Brugia malayi | geranylgeranyl pyrophosphate synthetase | 0.0113 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0168 | 0.1475 | 0.2273 |
Trypanosoma cruzi | squalene synthase, putative | 0.0353 | 0.649 | 1 |
Trypanosoma cruzi | squalene synthase, putative | 0.0353 | 0.649 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.1475 | 1 |
Mycobacterium ulcerans | phytoene synthase, CrtB | 0.0483 | 1 | 0.5 |
Onchocerca volvulus | NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog | 0.0168 | 0.1475 | 0.5 |
Treponema pallidum | octaprenyl-diphosphate synthase | 0.0113 | 0 | 0.5 |
Trypanosoma brucei | squalene synthase, putative | 0.0353 | 0.649 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.1475 | 1 |
Trypanosoma cruzi | phytoene synthase, putative | 0.0168 | 0.1475 | 0.2273 |
Echinococcus multilocularis | Squalene phytoene synthase | 0.0168 | 0.1475 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 99 uM | PUBCHEM_BIOASSAY: SAR Analysis of small molecule inhibitors of Sentrin-specific proteases (SENPs) using a Caspase-3 Selectivity assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2540, AID2599, AID434973, AID489001] | ChEMBL. | No reference |
IC50 (functional) | > 99 uM | PUBCHEM_BIOASSAY: SAR Analysis of small molecule inhibitors of Sentrin-specific protease 6 (SENP6) using a Luminescent assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2582, AID2599] | ChEMBL. | No reference |
IC50 (functional) | > 99 uM | PUBCHEM_BIOASSAY: SAR Analysis of small molecule inhibitors of Sentrin-specific protease 7 (SENP7) using a Luminescent assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID434973, AID434986] | ChEMBL. | No reference |
IC50 (functional) | > 99 uM | PUBCHEM_BIOASSAY: SAR Analysis of small molecule inhibitors of Sentrin-specific protease 8 (SENP8) using a Luminescent assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2540, AID2575] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.