Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0079 | 0.3146 | 0.311 | |
Brugia malayi | CAAX amino terminal protease family protein | 0.0077 | 0.3021 | 0.3466 |
Brugia malayi | Pre-SET motif family protein | 0.0175 | 0.8618 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0079 | 0.3146 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.3146 | 0.3612 |
Echinococcus multilocularis | CAAX prenyl protease 2 | 0.0077 | 0.3021 | 1 |
Giardia lamblia | Hypothetical protein | 0.0077 | 0.3021 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0079 | 0.3146 | 1 |
Echinococcus granulosus | CAAX prenyl protease 2 | 0.0077 | 0.3021 | 1 |
Leishmania major | CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) | 0.0077 | 0.3021 | 0.5 |
Schistosoma mansoni | family U48 unassigned peptidase (U48 family) | 0.0077 | 0.3021 | 0.9595 |
Schistosoma mansoni | family U48 unassigned peptidase (U48 family) | 0.0077 | 0.3021 | 0.9595 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.3146 | 0.3612 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0025 | 0.0053 | 0.0175 |
Brugia malayi | Trypsin family protein | 0.0079 | 0.3146 | 0.3612 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0025 | 0.0053 | 0.5 |
Entamoeba histolytica | CAAX prenyl protease family | 0.0077 | 0.3021 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.3021 | 0.3466 |
Trypanosoma cruzi | CAAX prenyl protease 2, putative | 0.0077 | 0.3021 | 0.5 |
Trypanosoma brucei | CAAX amino terminal protease, putative | 0.0077 | 0.3021 | 0.5 |
Trichomonas vaginalis | set domain proteins, putative | 0.0199 | 1 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0175 | 0.8618 | 1 |
Plasmodium vivax | SET domain protein, putative | 0.0025 | 0.0053 | 0.5 |
Onchocerca volvulus | 0.0074 | 0.2851 | 0.2813 | |
Trypanosoma cruzi | peptidase with unknown catalytic mechanism (family U48) | 0.0077 | 0.3021 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.