Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | heat shock protein 70 | 0.0004 | 0 | 0.5 |
Echinococcus granulosus | heat shock protein 70 | 0.0004 | 0 | 0.5 |
Echinococcus granulosus | heat shock protein 70 | 0.0004 | 0 | 0.5 |
Echinococcus multilocularis | Heat shock 70 kDa protein | 0.0004 | 0 | 0.5 |
Trichomonas vaginalis | heat shock protein, putative | 0.0004 | 0 | 0.5 |
Trichomonas vaginalis | heat shock protein 70kD, putative | 0.0004 | 0 | 0.5 |
Echinococcus multilocularis | heat shock protein 70 | 0.0004 | 0 | 0.5 |
Echinococcus granulosus | Heat shock 70 kDa protein 4 | 0.0004 | 0 | 0.5 |
Brugia malayi | Telomerase reverse transcriptase | 0.0255 | 0.7234 | 1 |
Echinococcus granulosus | heat shock protein 70 | 0.0004 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0004 | 0 | 0.5 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0096 | 0.264 | 1 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.0096 | 0.264 | 1 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0096 | 0.264 | 1 |
Leishmania major | telomerase reverse transcriptase, putative | 0.0096 | 0.264 | 1 |
Giardia lamblia | Telomerase catalytic subunit | 0.0096 | 0.264 | 1 |
Entamoeba histolytica | heat shock protein70, hsp70A2, putative | 0.0004 | 0 | 0.5 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.0096 | 0.264 | 1 |
Echinococcus multilocularis | heat shock protein | 0.0004 | 0 | 0.5 |
Echinococcus multilocularis | heat shock protein 70 | 0.0004 | 0 | 0.5 |
Echinococcus granulosus | heat shock protein 70 | 0.0004 | 0 | 0.5 |
Trichomonas vaginalis | heat shock protein, putative | 0.0004 | 0 | 0.5 |
Echinococcus granulosus | heat shock protein 70 | 0.0004 | 0 | 0.5 |
Echinococcus multilocularis | heat shock protein 70 related | 0.0004 | 0 | 0.5 |
Entamoeba histolytica | heat shock protein70, hsp70A2, putative | 0.0004 | 0 | 0.5 |
Trichomonas vaginalis | microsomal stress 70 protein ATPase core precursor, putative | 0.0004 | 0 | 0.5 |
Echinococcus multilocularis | heat shock protein 70 | 0.0004 | 0 | 0.5 |
Entamoeba histolytica | heat shock protein70, hsp70A2, putative | 0.0004 | 0 | 0.5 |
Echinococcus granulosus | Heat shock 70 kDa protein 4 | 0.0004 | 0 | 0.5 |
Echinococcus granulosus | heat shock protein 70 | 0.0004 | 0 | 0.5 |
Echinococcus granulosus | heat shock kda protein | 0.0004 | 0 | 0.5 |
Echinococcus multilocularis | Heat shock 70 kDa protein | 0.0004 | 0 | 0.5 |
Entamoeba histolytica | heat shock protein 70, putative | 0.0004 | 0 | 0.5 |
Echinococcus multilocularis | heat shock protein 70 | 0.0004 | 0 | 0.5 |
Echinococcus multilocularis | Heat shock 70 kDa protein 4 | 0.0004 | 0 | 0.5 |
Echinococcus multilocularis | heat shock protein 70 | 0.0004 | 0 | 0.5 |
Echinococcus multilocularis | heat shock protein kDa heat shock kDa protein | 0.0004 | 0 | 0.5 |
Echinococcus granulosus | heat shock protein 70 | 0.0004 | 0 | 0.5 |
Echinococcus granulosus | Heat Shock protein family member hsp 3 | 0.0004 | 0 | 0.5 |
Echinococcus multilocularis | Heat shock 70 kDa protein 4 | 0.0004 | 0 | 0.5 |
Echinococcus granulosus | heat shock protein 70 | 0.0004 | 0 | 0.5 |
Echinococcus multilocularis | Heat shock 70 kDa protein 4 | 0.0004 | 0 | 0.5 |
Echinococcus granulosus | heat shock protein | 0.0004 | 0 | 0.5 |
Echinococcus multilocularis | 0.0004 | 0 | 0.5 | |
Echinococcus granulosus | heat shock protein 70 | 0.0004 | 0 | 0.5 |
Trichomonas vaginalis | heat shock protein, putative | 0.0004 | 0 | 0.5 |
Echinococcus granulosus | heat shock protein 70 | 0.0004 | 0 | 0.5 |
Echinococcus multilocularis | heat shock 70 kDa protein 1 | 0.0004 | 0 | 0.5 |
Echinococcus granulosus | Heat shock 70 kDa protein | 0.0004 | 0 | 0.5 |
Echinococcus granulosus | heat shock protein 70 | 0.0004 | 0 | 0.5 |
Trichomonas vaginalis | heat shock protein 70 (HSP70)-4, putative | 0.0004 | 0 | 0.5 |
Echinococcus multilocularis | heat shock protein 70 | 0.0004 | 0 | 0.5 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0096 | 0.264 | 1 |
Echinococcus multilocularis | 0.0004 | 0 | 0.5 | |
Entamoeba histolytica | heat shock protein 70 family | 0.0004 | 0 | 0.5 |
Echinococcus granulosus | heat shock protein 70 | 0.0004 | 0 | 0.5 |
Trichomonas vaginalis | heat shock protein, putative | 0.0004 | 0 | 0.5 |
Echinococcus multilocularis | heat shock protein 70b | 0.0004 | 0 | 0.5 |
Echinococcus granulosus | heat shock protein 70 | 0.0004 | 0 | 0.5 |
Trichomonas vaginalis | heat shock protein, putative | 0.0004 | 0 | 0.5 |
Echinococcus granulosus | 3'partial|5'partial|heat shock protein 70 | 0.0004 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0004 | 0 | 0.5 |
Trichomonas vaginalis | heat shock protein, putative | 0.0004 | 0 | 0.5 |
Echinococcus granulosus | heat shock protein 70 | 0.0004 | 0 | 0.5 |
Echinococcus multilocularis | heat shock protein 70 | 0.0004 | 0 | 0.5 |
Echinococcus granulosus | heat shock protein 70 | 0.0004 | 0 | 0.5 |
Echinococcus multilocularis | Heat shock 70 kDa protein | 0.0004 | 0 | 0.5 |
Echinococcus granulosus | Heat shock 70 kDa protein 4 | 0.0004 | 0 | 0.5 |
Schistosoma mansoni | heat shock protein 70 | 0.0004 | 0 | 0.5 |
Entamoeba histolytica | 70 kDa heat shock protein, putative | 0.0004 | 0 | 0.5 |
Echinococcus granulosus | heat shock protein 70 | 0.0004 | 0 | 0.5 |
Echinococcus multilocularis | heat shock protein 70 related | 0.0004 | 0 | 0.5 |
Echinococcus granulosus | heat shock protein 70 | 0.0004 | 0 | 0.5 |
Entamoeba histolytica | heat shock protein 70 family | 0.0004 | 0 | 0.5 |
Echinococcus granulosus | heat shock protein 70 | 0.0004 | 0 | 0.5 |
Echinococcus multilocularis | heat shock protein 70 | 0.0004 | 0 | 0.5 |
Echinococcus multilocularis | heat shock protein 70 | 0.0004 | 0 | 0.5 |
Echinococcus granulosus | heat shock protein 70 | 0.0004 | 0 | 0.5 |
Entamoeba histolytica | heat shock protein 70, putative | 0.0004 | 0 | 0.5 |
Entamoeba histolytica | heat shock protein 70, putative | 0.0004 | 0 | 0.5 |
Echinococcus multilocularis | heat shock protein 70 | 0.0004 | 0 | 0.5 |
Echinococcus multilocularis | heat shock protein 71 kDa protein | 0.0004 | 0 | 0.5 |
Echinococcus multilocularis | heat shock 70 kda protein 1a | 0.0004 | 0 | 0.5 |
Echinococcus multilocularis | Heat Shock protein family member (hsp 3) | 0.0004 | 0 | 0.5 |
Echinococcus granulosus | heat shock protein 70 | 0.0004 | 0 | 0.5 |
Echinococcus granulosus | heat shock protein 71 kDa protein | 0.0004 | 0 | 0.5 |
Echinococcus granulosus | heat shock protein 71 kDa protein | 0.0004 | 0 | 0.5 |
Echinococcus granulosus | heat shock protein 70 | 0.0004 | 0 | 0.5 |
Echinococcus granulosus | heat shock protein 70 | 0.0004 | 0 | 0.5 |
Loa Loa (eye worm) | heat shock 70kDa protein 5 | 0.0004 | 0 | 0.5 |
Trichomonas vaginalis | heat shock protein 70 (HSP70)-4, putative | 0.0004 | 0 | 0.5 |
Echinococcus granulosus | Heat shock 70 kDa protein 4 | 0.0004 | 0 | 0.5 |
Echinococcus multilocularis | Heat shock 70 kDa protein | 0.0004 | 0 | 0.5 |
Echinococcus granulosus | heat shock protein 70 | 0.0004 | 0 | 0.5 |
Echinococcus granulosus | Heat shock 70 kDa protein | 0.0004 | 0 | 0.5 |
Echinococcus multilocularis | Heat shock 70 kDa protein | 0.0004 | 0 | 0.5 |
Echinococcus multilocularis | heat shock protein 70 | 0.0004 | 0 | 0.5 |
Echinococcus multilocularis | heat shock protein 70 related | 0.0004 | 0 | 0.5 |
Echinococcus multilocularis | heat shock protein 70 | 0.0004 | 0 | 0.5 |
Trichomonas vaginalis | heat shock protein, putative | 0.0004 | 0 | 0.5 |
Echinococcus multilocularis | heat shock protein 70 | 0.0004 | 0 | 0.5 |
Echinococcus granulosus | heat shock protein 70 | 0.0004 | 0 | 0.5 |
Trichomonas vaginalis | heat shock protein 70kD, putative | 0.0004 | 0 | 0.5 |
Echinococcus multilocularis | heat shock protein 71 kDa protein | 0.0004 | 0 | 0.5 |
Echinococcus granulosus | heat shock protein 70 | 0.0004 | 0 | 0.5 |
Echinococcus multilocularis | heat shock protein 70 | 0.0004 | 0 | 0.5 |
Trichomonas vaginalis | heat shock protein 70 (HSP70)-4, putative | 0.0004 | 0 | 0.5 |
Trichomonas vaginalis | heat shock protein, putative | 0.0004 | 0 | 0.5 |
Entamoeba histolytica | heat shock protein 70, putative | 0.0004 | 0 | 0.5 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.0096 | 0.264 | 1 |
Trichomonas vaginalis | heat shock protein, putative | 0.0004 | 0 | 0.5 |
Schistosoma mansoni | heat shock protein 70 | 0.0004 | 0 | 0.5 |
Echinococcus granulosus | heat shock protein 70 | 0.0004 | 0 | 0.5 |
Echinococcus granulosus | heat shock protein kDa | 0.0004 | 0 | 0.5 |
Schistosoma mansoni | heat shock protein 70 | 0.0004 | 0 | 0.5 |
Echinococcus multilocularis | heat shock protein kDa heat shock kDa protein | 0.0004 | 0 | 0.5 |
Echinococcus granulosus | heat shock protein 70b | 0.0004 | 0 | 0.5 |
Echinococcus multilocularis | 0.0004 | 0 | 0.5 | |
Echinococcus granulosus | heat shock protein 70 | 0.0004 | 0 | 0.5 |
Echinococcus multilocularis | heat shock 70 kDa protein 1A:1B | 0.0004 | 0 | 0.5 |
Echinococcus multilocularis | heat shock kda protein | 0.0004 | 0 | 0.5 |
Entamoeba histolytica | heat shock protein70, hsp70A2, putative | 0.0004 | 0 | 0.5 |
Echinococcus multilocularis | Heat shock 70 kDa protein | 0.0004 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 44.6684 uM | PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.