Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | heat shock protein70, hsp70A2, putative | 0.0003 | 0 | 0.5 |
Trichomonas vaginalis | heat shock protein, putative | 0.0003 | 0 | 0.5 |
Entamoeba histolytica | heat shock protein 70 family | 0.0003 | 0 | 0.5 |
Trichomonas vaginalis | heat shock protein 70kD, putative | 0.0003 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.5895 | 1 |
Entamoeba histolytica | heat shock protein70, hsp70A2, putative | 0.0003 | 0 | 0.5 |
Trichomonas vaginalis | heat shock protein, putative | 0.0003 | 0 | 0.5 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.0094 | 0.2669 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.5895 | 1 |
Trichomonas vaginalis | heat shock protein 70 (HSP70)-4, putative | 0.0003 | 0 | 0.5 |
Echinococcus multilocularis | geminin | 0.0205 | 0.5895 | 1 |
Entamoeba histolytica | heat shock protein70, hsp70A2, putative | 0.0003 | 0 | 0.5 |
Leishmania major | telomerase reverse transcriptase, putative | 0.0094 | 0.2669 | 1 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.0094 | 0.2669 | 1 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.0094 | 0.2669 | 1 |
Trichomonas vaginalis | heat shock protein, putative | 0.0003 | 0 | 0.5 |
Trichomonas vaginalis | heat shock protein, putative | 0.0003 | 0 | 0.5 |
Echinococcus granulosus | geminin | 0.0205 | 0.5895 | 1 |
Entamoeba histolytica | 70 kDa heat shock protein, putative | 0.0003 | 0 | 0.5 |
Entamoeba histolytica | heat shock protein 70, putative | 0.0003 | 0 | 0.5 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0094 | 0.2669 | 1 |
Trichomonas vaginalis | heat shock protein 70kD, putative | 0.0003 | 0 | 0.5 |
Trichomonas vaginalis | heat shock protein 70 (HSP70)-4, putative | 0.0003 | 0 | 0.5 |
Trichomonas vaginalis | heat shock protein 70 (HSP70)-4, putative | 0.0003 | 0 | 0.5 |
Entamoeba histolytica | heat shock protein70, hsp70A2, putative | 0.0003 | 0 | 0.5 |
Trichomonas vaginalis | heat shock protein, putative | 0.0003 | 0 | 0.5 |
Trichomonas vaginalis | heat shock protein, putative | 0.0003 | 0 | 0.5 |
Trichomonas vaginalis | heat shock protein, putative | 0.0003 | 0 | 0.5 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0094 | 0.2669 | 1 |
Entamoeba histolytica | heat shock protein 70, putative | 0.0003 | 0 | 0.5 |
Giardia lamblia | Telomerase catalytic subunit | 0.0094 | 0.2669 | 1 |
Trichomonas vaginalis | heat shock protein, putative | 0.0003 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0003 | 0 | 0.5 |
Trichomonas vaginalis | heat shock protein, putative | 0.0003 | 0 | 0.5 |
Entamoeba histolytica | heat shock protein 70, putative | 0.0003 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0003 | 0 | 0.5 |
Entamoeba histolytica | heat shock protein 70 family | 0.0003 | 0 | 0.5 |
Loa Loa (eye worm) | heat shock 70kDa protein 5 | 0.0003 | 0 | 0.5 |
Trichomonas vaginalis | microsomal stress 70 protein ATPase core precursor, putative | 0.0003 | 0 | 0.5 |
Brugia malayi | Telomerase reverse transcriptase | 0.0251 | 0.7245 | 1 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0094 | 0.2669 | 1 |
Entamoeba histolytica | heat shock protein 70, putative | 0.0003 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.4611 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.