Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | DNA polymerase IV | 0.0021 | 0 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.009 | 0.3145 | 1 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0021 | 0 | 0.5 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0068 | 0.2159 | 0.6864 |
Onchocerca volvulus | 0.0071 | 0.2262 | 0.5 | |
Echinococcus multilocularis | transcription factor Dp 1 | 0.004 | 0.0842 | 0.2678 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.024 | 1 | 1 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0021 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0651 | 0.3015 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0651 | 0.274 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0068 | 0.2159 | 1 |
Echinococcus granulosus | transcription factor Dp 1 | 0.004 | 0.0842 | 0.2678 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0021 | 0 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.0651 | 0.2069 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0021 | 0 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.009 | 0.3145 | 1 |
Brugia malayi | bZIP transcription factor family protein | 0.009 | 0.3145 | 0.3145 |
Echinococcus granulosus | jun protein | 0.009 | 0.3145 | 1 |
Echinococcus multilocularis | jun protein | 0.009 | 0.3145 | 1 |
Schistosoma mansoni | jun-related protein | 0.0073 | 0.2375 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0073 | 0.2375 | 1 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0068 | 0.2159 | 1 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0068 | 0.2159 | 0.2159 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0651 | 0.3015 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0068 | 0.2159 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.3032 | 0.3032 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.0651 | 0.2069 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0651 | 0.0651 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0068 | 0.2159 | 0.6864 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0651 | 0.3015 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0068 | 0.2159 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0068 | 0.2159 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0021 | 0 | 0.5 |
Giardia lamblia | DINP protein human, muc B family | 0.0021 | 0 | 0.5 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0068 | 0.2159 | 0.9091 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0651 | 0.3015 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0651 | 0.274 |
Brugia malayi | hypothetical protein | 0.0071 | 0.2262 | 0.2262 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0068 | 0.2159 | 0.2159 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.