Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0016 | 0 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0017 | 0.0099 | 0.0099 |
Schistosoma mansoni | tar DNA-binding protein | 0.0124 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0124 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.345 | 0.345 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0 | 0.5 |
Echinococcus multilocularis | GPCR, family 2 | 0.0017 | 0.0099 | 0.0099 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.0099 | 0.0099 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.1899 | 0.1899 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0099 | 0.0099 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.0099 | 0.0099 |
Loa Loa (eye worm) | RNA binding protein | 0.0124 | 1 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0016 | 0 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.345 | 0.345 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0016 | 0 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0124 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0124 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0124 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.1899 | 0.1899 |
Echinococcus granulosus | GPCR family 2 | 0.0017 | 0.0099 | 0.0099 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0017 | 0.0099 | 0.0099 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0099 | 0.0099 |
Loa Loa (eye worm) | TAR-binding protein | 0.0124 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0099 | 0.0099 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0124 | 1 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0016 | 0 | 0.5 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0016 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.345 | 0.345 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0017 | 0.0099 | 0.0099 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0016 | 0 | 0.5 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.0099 | 0.0099 |
Schistosoma mansoni | tar DNA-binding protein | 0.0124 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1899 | 0.1899 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.345 | 0.345 |
Schistosoma mansoni | tar DNA-binding protein | 0.0124 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0099 | 0.0099 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0124 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0124 | 1 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.0099 | 0.0099 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0016 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0099 | 0.0099 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.