Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | RNA recognition motif domain containing protein | 0.0131 | 0.5209 | 0.5557 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0195 | 0.9374 | 0.8693 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.008 | 0.1839 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0131 | 0.5209 | 0.4805 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.008 | 0.1839 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.5209 | 0.4457 |
Brugia malayi | TAR-binding protein | 0.0131 | 0.5209 | 0.5557 |
Mycobacterium tuberculosis | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA | 0.0153 | 0.6659 | 0.5 |
Mycobacterium leprae | PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA | 0.0153 | 0.6659 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.008 | 0.1839 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.5209 | 0.4457 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0195 | 0.9374 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.5209 | 0.4457 |
Leishmania major | hypothetical protein, conserved | 0.008 | 0.1839 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0195 | 0.9374 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.008 | 0.1839 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.0131 | 0.5209 | 0.5557 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0106 | 0.3535 | 0.3772 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.5209 | 0.4457 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.3535 | 0.2717 |
Trichomonas vaginalis | acetylornithine aminotransferase, putative | 0.0153 | 0.6659 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.5209 | 0.4457 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0195 | 0.9374 | 0.9275 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0195 | 0.9374 | 0.9275 |
Mycobacterium ulcerans | adenosylmethionine-8-amino-7-oxononanoate aminotransferase | 0.0153 | 0.6659 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0195 | 0.9374 | 0.8693 |
Loa Loa (eye worm) | TAR-binding protein | 0.0131 | 0.5209 | 0.4805 |
Echinococcus multilocularis | geminin | 0.0205 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0106 | 0.3535 | 0.2717 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.008 | 0.1839 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.008 | 0.1839 | 0.5 |
Brugia malayi | hypothetical protein | 0.008 | 0.1839 | 0.1962 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0195 | 0.9374 | 0.8693 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.008 | 0.1839 | 0.5 |
Mycobacterium tuberculosis | Probable aminotransferase | 0.0153 | 0.6659 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0106 | 0.3535 | 0.3772 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0195 | 0.9374 | 0.9275 |
Mycobacterium ulcerans | hypothetical protein | 0.0153 | 0.6659 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0131 | 0.5209 | 0.4805 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.1839 | 0.0601 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0072 | 0.1357 | 0.1448 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0195 | 0.9374 | 0.8693 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.8199 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 3.6964 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 37.933 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.