Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ATPase family, AAA domain containing 5 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | Get druggable targets OG5_139225 | All targets in OG5_139225 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0213 | 0.1789 | 0.1483 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0213 | 0.1789 | 0.4473 |
Schistosoma mansoni | hypothetical protein | 0.008 | 0.0359 | 0.1011 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.008 | 0.0356 | 0.5 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0187 | 0.1507 | 0.4237 |
Echinococcus granulosus | glutamate receptor 2 | 0.0133 | 0.0932 | 0.179 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0187 | 0.1507 | 1 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0378 | 0.3556 | 1 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0378 | 0.3556 | 1 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0213 | 0.1789 | 0.1483 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0187 | 0.1507 | 1 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0213 | 0.1789 | 0.4473 |
Brugia malayi | hypothetical protein | 0.008 | 0.0356 | 0.2083 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0215 | 0.1806 | 0.1501 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0117 | 0.076 | 0.0416 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0187 | 0.1507 | 0.4237 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.008 | 0.0356 | 0.5 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0213 | 0.1789 | 0.4473 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0304 | 0.2765 | 0.7776 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.008 | 0.0356 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0213 | 0.1789 | 0.1483 |
Schistosoma mansoni | glutamate receptor kainate | 0.0187 | 0.1507 | 0.4237 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.008 | 0.0356 | 0.5 |
Schistosoma mansoni | glutamate receptor kainate | 0.0187 | 0.1507 | 0.4237 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0187 | 0.1507 | 1 |
Schistosoma mansoni | glutamate receptor kainate | 0.0187 | 0.1507 | 0.4237 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0091 | 0.0478 | 0.0123 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0187 | 0.1507 | 0.119 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0213 | 0.1789 | 0.1483 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0117 | 0.076 | 0.1254 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0213 | 0.1789 | 0.4473 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0378 | 0.3556 | 0.3316 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0215 | 0.1806 | 0.4527 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.008 | 0.0356 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0124 | 0.083 | 0.0489 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0187 | 0.1507 | 1 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0091 | 0.0478 | 0.037 |
Leishmania major | hypothetical protein, conserved | 0.008 | 0.0356 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0213 | 0.1789 | 0.1483 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0133 | 0.0932 | 0.0594 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.008 | 0.0356 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.008 | 0.0356 | 0.5 |
Echinococcus granulosus | glutamate receptor 2 | 0.0213 | 0.1789 | 0.4473 |
Schistosoma mansoni | ATP-binding cassette transporter | 0.0187 | 0.1507 | 0.4237 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.2332 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 18.3489 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.