Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | RNA binding protein | 0.0186 | 0.3211 | 0.3211 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0373 | 0.0373 |
Schistosoma mansoni | tar DNA-binding protein | 0.0186 | 0.3211 | 0.3211 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 0.0694 | 0.0694 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0054 | 0.0694 | 0.0694 |
Loa Loa (eye worm) | TAR-binding protein | 0.0186 | 0.3211 | 0.3211 |
Echinococcus multilocularis | tar DNA binding protein | 0.0186 | 0.3211 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0186 | 0.3211 | 0.3211 |
Trichomonas vaginalis | glutaminase, putative | 0.0544 | 1 | 0.5 |
Loa Loa (eye worm) | glutaminase 2 | 0.0544 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.0373 | 0.0373 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0373 | 0.0373 |
Loa Loa (eye worm) | glutaminase | 0.0544 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0186 | 0.3211 | 0.3211 |
Echinococcus granulosus | tar DNA binding protein | 0.0186 | 0.3211 | 1 |
Mycobacterium ulcerans | glutaminase | 0.0544 | 1 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0186 | 0.3211 | 0.3211 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 0.0694 | 0.0694 |
Schistosoma mansoni | glutaminase | 0.0544 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0694 | 0.0694 |
Schistosoma mansoni | tar DNA-binding protein | 0.0186 | 0.3211 | 0.3211 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0186 | 0.3211 | 0.3211 |
Schistosoma mansoni | tar DNA-binding protein | 0.0186 | 0.3211 | 0.3211 |
Schistosoma mansoni | tar DNA-binding protein | 0.0186 | 0.3211 | 0.3211 |
Loa Loa (eye worm) | RNA binding protein | 0.0186 | 0.3211 | 0.3211 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 9.285 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 14.7157 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 20.5878 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.