Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0185 | 1 | 0.5 | |
Echinococcus multilocularis | cytidine deaminase | 0.0185 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable cytidine deaminase Cdd (cytidine aminohydrolase) (cytidine nucleoside deaminase) | 0.0185 | 1 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.1324 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.1324 | 0.1324 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0 | 0.5 |
Giardia lamblia | Cytidine deaminase | 0.0185 | 1 | 0.5 |
Entamoeba histolytica | cytidine deaminase, putative | 0.0185 | 1 | 0.5 |
Trichomonas vaginalis | cytidine deaminase, putative | 0.0185 | 1 | 0.5 |
Trichomonas vaginalis | cytidine deaminase, putative | 0.0185 | 1 | 0.5 |
Echinococcus granulosus | cytidine deaminase | 0.0185 | 1 | 0.5 |
Trypanosoma cruzi | cytidine deaminase-like protein | 0.0185 | 1 | 0.5 |
Trypanosoma cruzi | cytidine deaminase-like protein, putative | 0.0185 | 1 | 0.5 |
Trypanosoma brucei | cytidine deaminase | 0.0185 | 1 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.1324 | 0.1324 |
Mycobacterium leprae | PROBABLE CYTIDINE DEAMINASE CDD (CYTIDINE AMINOHYDROLASE) (CYTIDINE NUCLEOSIDE DEAMINASE) | 0.0185 | 1 | 0.5 |
Toxoplasma gondii | cytidine and deoxycytidylate deaminase zinc-binding region domain-containing protein | 0.0185 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1324 | 1 |
Onchocerca volvulus | 0.0185 | 1 | 0.5 | |
Mycobacterium ulcerans | cytidine deaminase | 0.0185 | 1 | 0.5 |
Leishmania major | cytidine deaminase-like protein | 0.0185 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 63.0957 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.