Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | cytidine deaminase, putative | 0.0186 | 1 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.1319 | 0.1319 |
Toxoplasma gondii | cytidine and deoxycytidylate deaminase zinc-binding region domain-containing protein | 0.0186 | 1 | 0.5 |
Trichomonas vaginalis | cytidine deaminase, putative | 0.0186 | 1 | 0.5 |
Onchocerca volvulus | 0.0186 | 1 | 0.5 | |
Mycobacterium leprae | PROBABLE CYTIDINE DEAMINASE CDD (CYTIDINE AMINOHYDROLASE) (CYTIDINE NUCLEOSIDE DEAMINASE) | 0.0186 | 1 | 0.5 |
Echinococcus multilocularis | cytidine deaminase | 0.0186 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable cytidine deaminase Cdd (cytidine aminohydrolase) (cytidine nucleoside deaminase) | 0.0186 | 1 | 0.5 |
Onchocerca volvulus | 0.0186 | 1 | 0.5 | |
Echinococcus granulosus | cytidine deaminase | 0.0186 | 1 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.1319 | 1 |
Leishmania major | cytidine deaminase-like protein | 0.0186 | 1 | 0.5 |
Trypanosoma cruzi | cytidine deaminase-like protein | 0.0186 | 1 | 0.5 |
Giardia lamblia | Cytidine deaminase | 0.0186 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.1319 | 0.1319 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1319 | 1 |
Trypanosoma brucei | cytidine deaminase | 0.0186 | 1 | 0.5 |
Mycobacterium ulcerans | cytidine deaminase | 0.0186 | 1 | 0.5 |
Trypanosoma cruzi | cytidine deaminase-like protein, putative | 0.0186 | 1 | 0.5 |
Entamoeba histolytica | cytidine deaminase, putative | 0.0186 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 8.9125 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.