Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ubiquitin specific peptidase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.5903 | 1 | 1 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.2345 | 0.2015 | 0.1799 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.4198 | 0.6174 | 0.5208 |
Trypanosoma brucei | prolyl endopeptidase | 0.4198 | 0.6174 | 1 |
Toxoplasma gondii | prolyl endopeptidase | 0.4198 | 0.6174 | 1 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.1938 | 0.1103 | 0.5 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.2345 | 0.2015 | 0.1799 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.5903 | 1 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.4198 | 0.6174 | 0.6174 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.1938 | 0.1103 | 0.5 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.5903 | 1 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.2345 | 0.2015 | 0.2015 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.2345 | 0.2015 | 0.1799 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.5903 | 1 | 1 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.2345 | 0.2015 | 0.1799 |
Echinococcus granulosus | prolyl endopeptidase | 0.4198 | 0.6174 | 0.5208 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.4198 | 0.6174 | 0.5208 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.5903 | 1 | 1 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.4198 | 0.6174 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.4198 | 0.6174 | 0.6174 |
Trypanosoma cruzi | prolyl endopeptidase | 0.4198 | 0.6174 | 1 |
Echinococcus multilocularis | prolyl endopeptidase | 0.4198 | 0.6174 | 0.5208 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.2345 | 0.2015 | 0.1799 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.3358 | 0.4289 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.5849 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 7.0795 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.